| Lacosamide in Refractory Mixed Pediatric Epilepsy: A Prospective Add-on Study. | |
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MedLine Citation:
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PMID: 22467791 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Lacosamide is a new antiepileptic drug that is currently approved by the US Food and Drug Administration (FDA) for adults 17 years or older for partial-onset seizures. The authors reviewed 21 pediatric patients (<17 years) with various seizure types who were started on oral lacosamide as part of a prospective add-on study as adjunctive therapy for refractory epilepsy. Five patients were excluded due to less than 3 months of meaningful follow-up. Maintenance dosages used ranged from 2.4 to 19.4 mg/kg/d. Eight of 16 (50%) patients had greater than 50% reduction in seizure frequency with adjunctive lacosamide therapy. Eight (50%) patients had generalized epilepsy including 4 with Lennox-Gastaut syndrome. Lacosamide was effective therapy for most seizure types but was particularly effective for partial-onset seizures. Lacosamide was effective in treating 5 of 8 (62.5%) localization-related epilepsies but only 2 of 8 (25%) generalized epilepsies, both Lennox-Gastaut syndrome patients with greater than 90% seizure reduction. None of these very refractory patients remained seizure free. |
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Authors:
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Reena Gogia Rastogi; Yu-Tze Ng |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child neurology Volume: 27 ISSN: 1708-8283 ISO Abbreviation: J. Child Neurol. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8606714 Medline TA: J Child Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 492-5 Citation Subset: IM |
Affiliation:
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1Division of Pediatric Neurology, Barrow Neurological Institute, Phoenix, AZ, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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