Document Detail


Lack of sister chromatid exchange induction in phenytoin-treated patients with epilepsy.
MedLine Citation:
PMID:  2924749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Phenytoin (PHT) has been suspected of having a mutagenic effect with chronic administration, but the existing evidence is equivocal. Contradictory results have been obtained using different testing systems. Sister chromatid exchange (SCE), a sensitive indicator of genotoxic environmental influences, has been used in only a few limited studies of PHT users, with varying results. The present study was designed to evaluate the potential mutagenicity of PHT in a more objective and reliable way than has been done previously. Following careful screening procedures, 16 adult male patients with epilepsy receiving long-term PHT monotherapy and 16 healthy controls were selected for a study of SCE frequencies in peripheral lymphocytes. The patients and controls were matched for sex, age, and smoking habits. Strict exclusionary criteria were observed, including all factors known to affect or suspected of affecting the SCE frequencies. Statistical analyses did not reveal any significant differences between the SCE rates of PHT-treated patients and controls, indicating a lack of PHT mutagenicity as expressed by induction of SCE in adults.
Authors:
B A Schaumann; V B Winge; V F Garry
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Epilepsia     Volume:  30     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:    1989 Mar-Apr
Date Detail:
Created Date:  1989-04-24     Completed Date:  1989-04-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
Affiliation:
Research Service, VA Medical Center, Minneapolis, MN 55147.
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MeSH Terms
Descriptor/Qualifier:
Adult
Epilepsy / drug therapy*
Humans
Lymphocytes / drug effects
Male
Middle Aged
Mutagens*
Phenytoin / adverse effects*,  blood,  therapeutic use
Sister Chromatid Exchange / drug effects*
Smoking / blood
Chemical
Reg. No./Substance:
0/Mutagens; 57-41-0/Phenytoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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