Document Detail


Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label-randomized clinical trial.
MedLine Citation:
PMID:  19419443     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To determine if the adjunctive use of intra-muscular neridronate (NE) during non-surgical periodontal treatment (PT) provides, in patients with generalized chronic periodontitis (GCP), adjunctive benefits as compared with PT alone 3 months after the completion of a 3-month NE therapy. MATERIAL AND METHODS: Sixty GCP healthy patients were randomly assigned to control (CG) or test group (TG). CG patients received PT only. Thirty subjects in TG also received adjunctive NE (12.5 mg in an i.m. injection/week for 3 months). Clinical parameters were evaluated at baseline, at the end of NE treatment (3 months after PT) and 3 months after the completion of NE treatment (6 months after the beginning of PT). RESULTS: Groups were balanced at baseline and all clinical parameters showed improvement between baseline and follow-ups. At 6 months improvements from baseline at sites with deep pocket depth (>or=7 mm) were 3.2 mm [95% confidence interval (CI): 2.7-3.9] in CG and 3.0 mm (95% CI: 2.3-3.8) in TG with a non-significant difference of 0.2 mm (95% CI: -1.0-0.5; ANCOVA; p=0.549) between groups. Secondary outcomes did not show significant differences between groups. No major adverse events were reported. CONCLUSIONS: The adjunctive use of NE during PT did not result in additional short-term improvements in periodontal conditions of GCP patients when compared with PT.
Authors:
Filippo Graziani; Silvia Cei; Adrian Guerrero; Fabio La Ferla; Michele Vano; Maurizio Tonetti; Mario Gabriele
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical periodontology     Volume:  36     ISSN:  1600-051X     ISO Abbreviation:  J. Clin. Periodontol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0425123     Medline TA:  J Clin Periodontol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  419-27     Citation Subset:  D; IM    
Affiliation:
Department of Surgery, Section of Oral Surgery, University of Pisa, Pisa, Italy. f.graziani@med.unipi.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Density Conservation Agents / administration & dosage,  adverse effects,  therapeutic use*
Chronic Periodontitis / drug therapy,  therapy*
Dental Plaque Index
Dental Scaling
Diphosphonates / administration & dosage,  adverse effects,  therapeutic use*
Disease Progression
Female
Follow-Up Studies
Gingival Hemorrhage / drug therapy,  therapy
Gingival Recession / drug therapy,  therapy
Humans
Injections, Intramuscular
Male
Oral Hygiene
Periodontal Attachment Loss / drug therapy,  therapy
Periodontal Pocket / drug therapy,  therapy
Root Planing
Single-Blind Method
Treatment Outcome
Chemical
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Diphosphonates; 79778-41-9/6-amino-1-hydroxyhexane-1,1-diphosphonate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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