| Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure. | |
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MedLine Citation:
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PMID: 21448568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serotonin (5-hydroxytryptamine; 5-HT) is a potent constrictor of isolated blood vessels. However, recent studies demonstrate that chronic 5-HT infusion results in a prolonged fall in blood pressure in the rat. This finding highlights the need for further study of 5-HT in the cardiovascular system. We tested the hypothesis that a functional serotonin transporter (SERT) is critical to enabling a 5-HT-induced fall in blood pressure. Experiments were performed in male and female rats to determine whether gender significantly affected the ability of 5-HT to lower blood pressure and to determine whether SERT dependence was different in male vs. female rats. 5-HT (25 μg/kg/min; s.c.) was infused for 7 days to male and female, SERT wild-type (WT) and SERT knockout (KO) rats. Mean arterial pressure (MAP) and heart rate were monitored via radiotelemetry. 5-HT produced a significantly greater fall in MAP (at the nadir) in the male SERT WT rat (-20 ± 1 mmHg) compared to the male SERT KO rat (-10 ± 2 mmHg). Similarly, 5-HT also produced a significantly greater fall in MAP (at the nadir) in the female SERT WT rat (-19 ± 1 mmHg) compared to the female SERT KO rat (-15 ± 0.4 mmHg). While the lack of a functional SERT protein did not prevent a 5-HT-induced fall in blood pressure, it did reduce the ability of 5-HT to lower blood pressure in the male and female SERT rat, suggesting a potentially important role for SERT in producing a 5-HT-induced fall in blood pressure. |
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Authors:
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Robert Patrick Davis; A Elizabeth Linder; Stephanie W Watts |
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Publication Detail:
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Type: Journal Article Date: 2011-03-30 |
Journal Detail:
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Title: Naunyn-Schmiedeberg's archives of pharmacology Volume: 383 ISSN: 1432-1912 ISO Abbreviation: Naunyn Schmiedebergs Arch. Pharmacol. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-04-27 Completed Date: 2011-09-02 Revised Date: 2012-09-24 |
Medline Journal Info:
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Nlm Unique ID: 0326264 Medline TA: Naunyn Schmiedebergs Arch Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 543-6 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824-1317, USA. davisr15@msu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Blotting, Western Data Interpretation, Statistical Female Heart Rate / drug effects Immunohistochemistry Male Rats Rats, Mutant Strains Rats, Wistar Serotonin / blood, pharmacology*, physiology Serotonin Plasma Membrane Transport Proteins / deficiency, genetics, physiology* Sex Characteristics |
| Grant Support | |
ID/Acronym/Agency:
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F30 HL099024-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Plasma Membrane Transport Proteins; 0/Slc6a4 protein, rat; 50-67-9/Serotonin |
| Comments/Corrections | |
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