Document Detail


Lack of the serotonin transporter (SERT) reduces the ability of 5-hydroxytryptamine to lower blood pressure.
MedLine Citation:
PMID:  21448568     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serotonin (5-hydroxytryptamine; 5-HT) is a potent constrictor of isolated blood vessels. However, recent studies demonstrate that chronic 5-HT infusion results in a prolonged fall in blood pressure in the rat. This finding highlights the need for further study of 5-HT in the cardiovascular system. We tested the hypothesis that a functional serotonin transporter (SERT) is critical to enabling a 5-HT-induced fall in blood pressure. Experiments were performed in male and female rats to determine whether gender significantly affected the ability of 5-HT to lower blood pressure and to determine whether SERT dependence was different in male vs. female rats. 5-HT (25 μg/kg/min; s.c.) was infused for 7 days to male and female, SERT wild-type (WT) and SERT knockout (KO) rats. Mean arterial pressure (MAP) and heart rate were monitored via radiotelemetry. 5-HT produced a significantly greater fall in MAP (at the nadir) in the male SERT WT rat (-20 ± 1 mmHg) compared to the male SERT KO rat (-10 ± 2 mmHg). Similarly, 5-HT also produced a significantly greater fall in MAP (at the nadir) in the female SERT WT rat (-19 ± 1 mmHg) compared to the female SERT KO rat (-15 ± 0.4 mmHg). While the lack of a functional SERT protein did not prevent a 5-HT-induced fall in blood pressure, it did reduce the ability of 5-HT to lower blood pressure in the male and female SERT rat, suggesting a potentially important role for SERT in producing a 5-HT-induced fall in blood pressure.
Authors:
Robert Patrick Davis; A Elizabeth Linder; Stephanie W Watts
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Publication Detail:
Type:  Journal Article     Date:  2011-03-30
Journal Detail:
Title:  Naunyn-Schmiedeberg's archives of pharmacology     Volume:  383     ISSN:  1432-1912     ISO Abbreviation:  Naunyn Schmiedebergs Arch. Pharmacol.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-27     Completed Date:  2011-09-02     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0326264     Medline TA:  Naunyn Schmiedebergs Arch Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  543-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, 48824-1317, USA. davisr15@msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Blotting, Western
Data Interpretation, Statistical
Female
Heart Rate / drug effects
Immunohistochemistry
Male
Rats
Rats, Mutant Strains
Rats, Wistar
Serotonin / blood,  pharmacology*,  physiology
Serotonin Plasma Membrane Transport Proteins / deficiency,  genetics,  physiology*
Sex Characteristics
Grant Support
ID/Acronym/Agency:
F30 HL099024-02/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Plasma Membrane Transport Proteins; 0/Slc6a4 protein, rat; 50-67-9/Serotonin
Comments/Corrections

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