Document Detail


Lack of risk of adverse birth outcomes after deworming in pregnant women.
MedLine Citation:
PMID:  16940835     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pregnant women who live in hookworm-endemic areas may benefit from deworming during their pregnancy. The benefit derives from reducing anemia, primarily iron-deficiency anemia caused by hookworm infection-attributable blood loss. Where the prevalence of hookworm is more than 20% to 30%, the World Health Organization recommends that pregnant women receive anthelminthic treatment (mebendazole, albendazole, levamisole or pyrantel) after their first trimester. The objective of this study is to report, describe and compare the occurrence of adverse birth outcomes in a large randomized, controlled trial of antenatal mebendazole (500 mg single dose) plus iron supplements versus placebo plus iron supplements conducted between April 2003 and June 2004 in the Amazon region of Peru. METHODS: Physician-recorded data on adverse birth outcomes occurring during the trial (N = 1042) were obtained. Proportions were compared using chi analysis. RESULTS: No statistically significant difference (P = 0.664) was found between the mebendazole group and the placebo group in terms of numbers of miscarriages, malformations, stillbirths, early neonatal deaths and premature babies (28 versus 31, respectively). CONCLUSIONS: The evidence provided by this large randomized, controlled trial of mebendazole administered during pregnancy indicates that deworming with mebendazole can be safely included in antenatal care programs in hookworm-endemic areas.
Authors:
Theresa W Gyorkos; Renee Larocque; Martin Casapia; Eduardo Gotuzzo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  25     ISSN:  0891-3668     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-08-30     Completed Date:  2006-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  791-4     Citation Subset:  IM    
Affiliation:
Division of Clinical Epidemiology, Department of Medicine, McGill University Health Centre, Montréal, Canada. theresa.gyorkos@mcgill.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Antinematodal Agents / adverse effects*,  therapeutic use
Birth Weight / drug effects
Double-Blind Method
Endemic Diseases
Female
Hookworm Infections / drug therapy*,  epidemiology
Humans
Mebendazole / adverse effects*,  therapeutic use
Mortality / trends
Peru / epidemiology
Pregnancy
Pregnancy Complications, Parasitic / drug therapy*
Pregnancy Outcome*
Premature Birth / chemically induced
Stillbirth / epidemiology
Chemical
Reg. No./Substance:
0/Antinematodal Agents; 31431-39-7/Mebendazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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