Document Detail


Lack of response to suramin in patients with AIDS and AIDS-related complex.
MedLine Citation:
PMID:  3548350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Forty-one homosexual men with the acquired immune deficiency syndrome (AIDS) or AIDS-related complex were treated with 0.5, 1.0, or 1.5 g of suramin weekly for up to six months. In no patient was evidence of symptomatic improvement or regression of Kaposi's sarcoma shown. Opportunistic infections developed in 16 patients during therapy. Only six patients (15 percent) became human immunodeficiency virus (HIV) culture-negative during treatment, despite documentation of adequate serum suramin levels. All but one of these six have had disease progression. Decreases in the numbers of total T4 cells with time were observed in both AIDS and AIDS-related complex subgroups. Toxicity was significant and consisted of fatigue, fever, and hepatic and renal dysfunction, all of which were observed most frequently with the 1.0 or 1.5 g dosages. Fatal hepatic failure developed in two patients, and adrenal insufficiency was documented in eight patients. Suramin is a toxic agent that shows no virologic, immunologic, or clinical benefit in patients with HIV-related disease.
Authors:
L D Kaplan; P R Wolfe; P A Volberding; P Feorino; J A Levy; D I Abrams; D Kiprov; R Wong; L Kaufman; M S Gottlieb
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  82     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-04-21     Completed Date:  1987-04-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-20     Citation Subset:  AIM; IM; X    
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Complex / blood,  drug therapy*,  immunology
Acquired Immunodeficiency Syndrome / blood,  drug therapy*,  immunology
Adult
Clinical Trials as Topic
Drug Administration Schedule
HIV / drug effects
Humans
Male
Suramin / adverse effects,  blood,  therapeutic use*
T-Lymphocytes / immunology
Virus Replication / drug effects
Chemical
Reg. No./Substance:
145-63-1/Suramin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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