| Lack of prejunctional modulation of noradrenaline release by endogenous nitric oxide in guinea pig pulmonary artery. | |
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MedLine Citation:
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PMID: 12106779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The regulation of noradrenaline (NA) release by endogenous endothelium-derived compounds was investigated in the isolated guinea pig pulmonary artery preloaded with [3H]NA. The radioactivity uptake, the basal and electrical field stimulation (10 Hz, 2 ms, 360 shocks) evoked release of [(3)H]NA was similar in arteries with intact endothelium and after removal of the endothelium. The wide selectivity nitric oxide (NO) synthase inhibitor N-omega-nitro-L-arginine (100 microM) did not affect significantly the basal and stimulation-evoked release of [(3)H]NA in control and endothelium-denuded preparations. These results indicate that neither endogenous NO nor other compounds derived from the endothelium have substantial influence on the NA outflow from sympathetic nerves innervating the pulmonary artery. |
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Authors:
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Attila Brassai; Katalin Makó; László Domjanschitz; Beáta Sperlágh |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochemistry international Volume: 41 ISSN: 0197-0186 ISO Abbreviation: Neurochem. Int. Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-07-10 Completed Date: 2002-10-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8006959 Medline TA: Neurochem Int Country: England |
Other Details:
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Languages: eng Pagination: 279-83 Citation Subset: IM |
Affiliation:
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University of Medicine and Pharmacy, Tirgu-Mures, Romania. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electric Stimulation Enzyme Inhibitors / pharmacology Guinea Pigs Male Nitric Oxide / metabolism* Nitric Oxide Synthase / antagonists & inhibitors Nitroarginine / pharmacology Norepinephrine / metabolism* Pulmonary Artery / metabolism*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 2149-70-4/Nitroarginine; 51-41-2/Norepinephrine; EC 1.14.13.39/Nitric Oxide Synthase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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