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Lack of precision in HbA(1c) values on variant II in cases of hemoglobin Q India.
MedLine Citation:
PMID:  23105618     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
This study was carried out to check the precision of HbA(1c) values on Bio-Rad Variant II in cases of a rare hemoglobin variant Q India. The study was carried out over a three month period on samples collected for HbA(1c) estimation. Seven out of eleven patients showed variable results of HbA(1c) with a very high and unacceptable intraday mean coefficient of variation (CV) of 9.93%. We conclude, that the results of HbA(1c) on Variant II can not be reported without adversely affecting HbA(1c) as a marker of long-term glycemic control in patients who have hemoglobin Q India. The HbA(1c) value of these patients needs to be assessed by a different instrument/method or the glycemic control be monitored by an alternate test like serum Fructosamine.
Authors:
P K Nigam; S Sharma; R Sareen; V Paul; A Lal
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of clinical biochemistry : IJCB     Volume:  21     ISSN:  0970-1915     ISO Abbreviation:  Indian J Clin Biochem     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2012-10-29     Completed Date:  2012-10-30     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  8708303     Medline TA:  Indian J Clin Biochem     Country:  India    
Other Details:
Languages:  eng     Pagination:  72-5     Citation Subset:  -    
Affiliation:
Dr Lal PathLabs Pvt Ltd, 'ESKAY HOUSE', 54, Hanuman Road, 110001 New Delhi, India.
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