| Lack of modulation of gastric emptying by dietary nitrate in healthy volunteers. | |
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MedLine Citation:
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PMID: 19398876 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitric oxide produced endogenously in vagal neurons modulates gastrointestinal motor activity as an important non-adrenergic and non-cholinergic neurotransmitter. Other than through endogenous biosynthesis, a high concentration of nitric oxide also occurs by chemical reactions within the stomach in the presence of gastric acid through the entero-salivary re-circulation of dietary nitrate. Although dietary nitrate can be a potential source of nitric oxide in the human stomach, there has been no report on the effect of dietary nitrate on gastric motor function. The aim of this study is to investigate the effect of dietary nitrate on gastric emptying, one of the major parameters for the gastric motor function. Fifteen healthy volunteers underwent a placebo-controlled (310 mg sodium nitrate or placebo), double-blind, crossover trial. Since a sufficient amount of gastric acid is essential for dietary nitrate-derived nitric oxide generation in the stomach, the same protocol was repeated after 1-week treatment with a proton pump inhibitor, rabeprazole. Gastric emptying was evaluated by (13)C-octanoate breath test. The sodium nitrate ingestion did not affect gastric emptying either prior to or during rabeprazole treatment, although rabeprazole treatment itself significantly delayed gastric emptying, being independent of the dietary nitrate load. Confirmation of the delayed gastric emptying with rabeprazole indicates the sensitivity of the breath test employed in the present study. In conclusion, despite the potential nitrogen source of exogenous nitric oxide, the ingestion of 310 mg sodium nitrate, which is equivalent to the average daily intake of Japanese adults, does not affect gastric emptying in healthy volunteers. |
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Authors:
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Shiho Terai; Katsunori Iijima; Kiyotaka Asanuma; Nobuyuki Ara; Kaname Uno; Yasuhiko Abe; Tomoyuki Koike; Akira Imatani; Shuichi Ohara; Tooru Shimosegawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 218 ISSN: 1349-3329 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-05-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: Japan |
Other Details:
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Languages: eng Pagination: 73-9 Citation Subset: IM |
Affiliation:
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Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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2-Pyridinylmethylsulfinylbenzimidazoles
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pharmacology Adolescent Adult Anti-Ulcer Agents / pharmacology Breath Tests Caprylates / metabolism Diet* Gastric Emptying / drug effects, physiology* Humans Male Nitrates* / administration & dosage, metabolism Nitrites / metabolism Saliva / chemistry Young Adult |
| Chemical | |
Reg. No./Substance:
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0/2-Pyridinylmethylsulfinylbenzimidazoles; 0/Anti-Ulcer Agents; 0/Caprylates; 0/Nitrates; 0/Nitrites; 124-07-2/octanoic acid; 32828355LL/rabeprazole |
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