Document Detail

Lack of long-term monoamine depletions following repeated or continuous exposure to cocaine.
MedLine Citation:
PMID:  2461246     Owner:  NLM     Status:  MEDLINE    
Cocaine was administered to rats for prolonged periods either by repeated injections (10 mg/kg twice daily for 10 days and 12.5 mg/kg 8 times daily for 10 days) or by continuous intravenous infusion (100 mg/kg/day for 21 days). None of the regimens produced long-lasting depletions of dopamine (DA), serotonin (5-HT), or major metabolites in striatum, hippocampus, hypothalamus, or somatosensory cortex. These results suggest that prolonged exposure to cocaine does not produce neurotoxicity like that observed with d-amphetamine or d-methylamphetamine.
M S Kleven; W L Woolverton; L S Seiden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research bulletin     Volume:  21     ISSN:  0361-9230     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-12-27     Completed Date:  1988-12-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Department of Pharmacology, University of Chicago, IL 60637.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Amphetamine / pharmacology
Biogenic Monoamines / metabolism*
Brain / drug effects*,  metabolism
Brain Chemistry / drug effects
Cocaine / pharmacology*
Dopamine / metabolism
Hydroxyindoleacetic Acid / metabolism
Hypothalamus / drug effects,  metabolism
Limbic System / drug effects,  metabolism
Methamphetamine / pharmacology
Rats, Inbred Strains
Serotonin / metabolism
Grant Support
Reg. No./Substance:
0/Biogenic Monoamines; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 300-62-9/Amphetamine; 50-36-2/Cocaine; 50-67-9/Serotonin; 537-46-2/Methamphetamine; 54-16-0/Hydroxyindoleacetic Acid

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