Document Detail

Lack of intravenous lidocaine effects on HRV changes of tracheal intubation during induction of general anesthesia.
MedLine Citation:
PMID:  11475179     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Intravenous lidocaine has been widely used for suppressing the autonomic activation from tracheal intubation during induction of general anesthesia. Conventionally, researches of its effectiveness through assessment of heart rate and blood pressure changes obtained by common clinical methods result in the conclusions deduced of much controversy. Heart rate variability is a noninvasive measurement of autonomic regulation and is suitable for the study of this subject.
METHODS: 36 ASA class I-II patients undergoing general anesthesia were divided into 3 groups. Besides induction agents, intravenous lidocaine was given 5 min before tracheal intubation in group A, 3 min before intubation in group B and nothing in group C. HRV spectral powers were measured at awake state, anesthetized state before tracheal intubation and anesthetized state after tracheal intubation by time frequency spectral analysis method and comparison was made between the three groups.
RESULTS: The HRV spectral power in high frequency (HF) and mid-frequency (MF) power bands and their ratios (MF/HF) were not significantly different among the 3 groups during the 3 observation periods.
CONCLUSIONS: There was no evidence to indicate the effectiveness of intravenous lidocaine on the autonomic regulation during tracheal intubation under the influence of induction agents used in general anesthesia.
P L Lin; Y P Wang; Y M Chou; H L Chan; H H Huang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Sinica     Volume:  39     ISSN:  0254-1319     ISO Abbreviation:  Acta Anaesthesiol. Sin.     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-08-16     Revised Date:  2014-07-14    
Medline Journal Info:
Nlm Unique ID:  9432542     Medline TA:  Acta Anaesthesiol Sin     Country:  China (Republic: 1949- )    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  IM    
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MeSH Terms
Anesthesia, General*
Anesthetics, Local / pharmacology*
Heart Rate / drug effects*
Injections, Intravenous
Intubation, Intratracheal*
Lidocaine / administration & dosage,  blood,  pharmacology*
Reg. No./Substance:
0/Anesthetics, Local; 98PI200987/Lidocaine

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