Document Detail

Lack of inhibition of vasopressin-stimulated NA+K+ATPase by atrial natriuretic factor in the rat renal medullary thick ascending limb of Henle's loop.
MedLine Citation:
PMID:  2160336     Owner:  NLM     Status:  MEDLINE    
The anti-diuretic hormone, arginine vasopressin (AVP) stimulates the activity of Na+K+ATPase in the rat renal medullary thick ascending limb of Henle's loop (mTAL). Atrial natriuretic factor (ANF) has been suggested to exert a tubular effect on the mammalian nephron, perhaps in part, by interacting with other hormones. In the present study, we investigated the effect of rat ANF with and without AVP upon mTAL Na+K+ATPase activity using cytochemical methods. ANF alone failed to inhibit or stimulate Na+K+ATPase activity in mTAL at any of the concentrations tested (10 nmol-0.1 pmol l-1). Unlike the rat hypothalamic digitalis-like factor, ANF (10 nmol-10 fmol l-1) did not inhibit Na+K+ATPase activity after stimulation with AVP (1 fmol l-1) for either 4 or 10 min. The results suggest that ANF does not exert an effect on mTAL, either alone or in conjunction with AVP.
J A Charlton; P H Baylis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biochemistry and function     Volume:  8     ISSN:  0263-6484     ISO Abbreviation:  Cell Biochem. Funct.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-06-28     Completed Date:  1990-06-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8305874     Medline TA:  Cell Biochem Funct     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Department of Medicine, Medical School, Newcastle-upon-Tyne, U.K.
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MeSH Terms
Analysis of Variance
Atrial Natriuretic Factor / pharmacology*
Kidney Medulla / drug effects,  enzymology*
Kidney Tubules / enzymology*
Loop of Henle / drug effects,  enzymology*
Rats, Inbred Strains
Sodium-Potassium-Exchanging ATPase / antagonists & inhibitors*
Vasopressins / pharmacology*
Reg. No./Substance:
0/atrial natriuretic peptide, rat; 11000-17-2/Vasopressins; 85637-73-6/Atrial Natriuretic Factor; EC ATPase

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