Document Detail

Lack of influence of volume flux on phosphate reabsorption in the proximal tubule.
MedLine Citation:
PMID:  3627047     Owner:  NLM     Status:  MEDLINE    
We examined the effects of changes in volume flux, with or without changes in sodium flux, on phosphate reabsorption in the proximal convoluted tubule of the rabbit. Experiments were performed: before and after the addition of 10(-5) M ouabain, with a bath of 260, 290, or 320 mosm/kg and a perfusate of 290, and with change in perfusion rate from 15 to 5 nl/min. With the addition of ouabain, volume reabsorption was completely inhibited and phosphate flux decreased significantly. When volume flux was altered without a corresponding change in sodium flux by altering bath osmolality, no change in phosphate flux was noted even though volume flux increased with the hyperosmotic bath and decreased with the hypoosmotic bath. When perfusion rate was decreased from 15 to 5 nl/min, volume reabsorption decreased by 47% and phosphate reabsorption decreased by 45%. Under these circumstances net sodium flux would be expected to decrease. These results are consistent with a relationship between phosphate and sodium, but not fluid, reabsorption. Furthermore, the absence of a relationship between phosphate and volume flux driven by osmotic gradients would suggest that the paracellular pathway is not a significant route of phosphate flux.
J S Kaufman; R J Hamburger
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mineral and electrolyte metabolism     Volume:  13     ISSN:  0378-0392     ISO Abbreviation:  Miner Electrolyte Metab     Publication Date:  1987  
Date Detail:
Created Date:  1987-10-14     Completed Date:  1987-10-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7802196     Medline TA:  Miner Electrolyte Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  158-64     Citation Subset:  IM    
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MeSH Terms
Kidney Tubules, Proximal / metabolism*
Osmolar Concentration
Ouabain / pharmacology
Phosphates / metabolism*
Raffinose / pharmacology
Sodium / metabolism
Grant Support
Reg. No./Substance:
0/Phosphates; 512-69-6/Raffinose; 630-60-4/Ouabain; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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