Document Detail

Lack of influence of circulating adrenaline on blood pressure in normotensive and hypertensive rats.
MedLine Citation:
PMID:  8199711     Owner:  NLM     Status:  MEDLINE    
The relationship between circulating adrenaline and blood pressure was examined by manipulating plasma adrenaline levels in both normotensive and hypertensive rats: bilateral adrenalmedullectomy was performed in spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats; adrenaline bitartrate was infused chronically (25-32 micrograms/kg/h s.c.) into Wistar Kyoto, Sprague Dawley and stroke-prone rats via osmotic minipumps. Arterial and venous catheters were subsequently implanted for direct measurement of mean arterial pressure, blood sampling and drug administration in conscious rats. Adrenaline infusion for 5-6 weeks in Wistar Kyoto rats did not affect resting blood pressure (118 +/- 3 versus 119 +/- 1 mmHg in controls) even though plasma adrenaline was elevated 12-fold. Plasma noradrenaline was marginally elevated. Blood pressure was also unaffected by adrenaline infusion in Sprague Dawley or stroke-prone hypertensive rats. One week after adrenal medullectomy, plasma adrenaline was reduced 89% in spontaneously hypertensive rats, but blood pressure was unaffected. Ten weeks after adrenal medullectomy in young stroke-prone rats, resting blood pressure was slightly higher (167 +/- 2 mmHg) than in control rats (157 +/- 2 mmHg), although adrenaline was reduced by 34% in plasma and 67% in adrenal glands. Nitroprusside was infused acutely to lower blood pressure and reflexly elevate plasma noradrenaline. Neither of these responses were affected by chronic adrenaline infusion or adrenal medullectomy. In both adrenaline-infused Wistar Kyoto and medullectomised stroke-prone rats, autonomic blockade reduced blood pressure to a similar extent as in controls, indicating that the degree of sympathetic vasoconstriction was not altered by either treatment.(ABSTRACT TRUNCATED AT 250 WORDS)
L T Jablonskis; P R Howe
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood pressure     Volume:  3     ISSN:  0803-7051     ISO Abbreviation:  Blood Press.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-07-01     Completed Date:  1994-07-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9301454     Medline TA:  Blood Press     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  112-9     Citation Subset:  IM    
Division of Human Nutrition, Commonwealth Scientific and Industrial Research Organisation, Adelaide, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adrenal Medulla / physiology
Blood Pressure* / drug effects
Epinephrine / blood*,  pharmacology
Hypertension / blood*,  physiopathology*
Infusion Pumps
Infusions, Intravenous
Nitroprusside / pharmacology
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Sprague-Dawley
Reference Values
Reg. No./Substance:
15078-28-1/Nitroprusside; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Elevated plasma adrenaline in spontaneously hypertensive rats.
Next Document:  Dietary fish oil administration retards blood pressure development and influences vascular propertie...