| Lack of induction of somatic aneuploidy in the mouse by nitrilotriacetic acid (NTA). | |
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MedLine Citation:
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PMID: 2733716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrilotriacetic acid (NTA) was tested for the induction of aneuploidy in mouse bone marrow cells. Doses of 138 or 275 mg/kg of body weight were intraperitoneally injected 24 h after implantation of a bromodeoxyuridine tablet. Cell-replication kinetics was assessed by comparing the relative percentages of first, second and third metaphases in control and treated samples. The hyperploidy incidence was estimated in second metaphases only, together with the SCE/cell level. Mice injected with 1.8 mg/kg vinblastine (VBL) were used as positive controls. A slight delay of cell cycle was induced by NTA, as shown by regression analysis applied to average generation time values. No increase over the control level was observed for hyperploidy or SCE induction in NTA-treated mice. VBL induced both cell-cycle alteration and a highly significant (P less than 0.001) increase of the hyperploid cell frequency. On the basis of these and previous (Costa et al., 1988) observations it seems that the non-disjunctional activity of NTA in the mouse is confined to meiotic processes. |
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Authors:
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A Russo; F Pacchierotti; B Bassani; A G Levis |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Mutation research Volume: 226 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1989 Jun |
Date Detail:
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Created Date: 1989-07-20 Completed Date: 1989-07-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 111-4 Citation Subset: IM |
Affiliation:
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Department of Biology, University of Padova, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetic Acids
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toxicity* Aneuploidy / drug effects* Animals Bone Marrow Cells Cell Cycle / drug effects Mice Micronucleus Tests Nitrilotriacetic Acid / toxicity* Sister Chromatid Exchange / drug effects Vinblastine / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Acetic Acids; 139-13-9/Nitrilotriacetic Acid; 865-21-4/Vinblastine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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