| Lack of impact of myocardial ischemia on the signal-averaged ECG assessment by time-domain analysis. | |
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MedLine Citation:
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PMID: 12167178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Late potentials represent an arrhythmogenic substrate in chronically infarcted myocardium. It is hypothesized that acute transient ischemia enhances anisotropic electrical ventricular activation and facilitates reentry mechanisms. Study aim was the prospective assessment of the impact of dipyridamole-induced myocardial ischemia on the signal-averaged ECG. METHODS: Dipyridamole stress thallium-201 SPECT imaging was utilized to avoid noise contamination of the signal-averaged ECG from exercise and to document evidence and localization of myocardial ischemia or persistent perfusion defects in 68 patients with suspected coronary artery disease. Before and during dipyridamole-induced vasodilatation serial signal-averaged ECG was performed to evaluate the influence of transient ischemia on the occurrence of late potentials. RESULTS: There was a significant difference between heart rate at rest and heart rate under dipyridamole influence in patients with inducible ischemia (70 +/- 13 vs. 87 +/- 13; P < 0.0001) in contrast to patients without dipyridamole-induced ischemia (74 +/- 20 vs. 80 +/- 16; n.s.). The number of averaged beats and achieved noise level was comparable between both groups. Thirty-three of 68 patients (49%) revealed dipyridamole-induced ischemia; however, no changes of the SAECG parameters, such as QRS, RMS, LAS at 25-250 and 40-250 Hz bandpass filtering in the leads X, Y, Z and vector magnitude, respectively, were observed as a result of ischemia. CONCLUSION: These results suggest that transient myocardial ischemia does not affect the signal-averaged ECG. Clinically, the signal-averaged ECG analysis seems not to be helpful in identifying patients with silent ischemia. |
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Authors:
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Michael A E Schneider; Christoph A Nienaber |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc Volume: 7 ISSN: 1082-720X ISO Abbreviation: Ann Noninvasive Electrocardiol Publication Date: 2002 Jul |
Date Detail:
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Created Date: 2002-08-08 Completed Date: 2002-10-11 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9607443 Medline TA: Ann Noninvasive Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 191-7 Citation Subset: IM |
Affiliation:
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German Heart Center, Munich, Germany. SchneiderM@DHM.mhn.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Analysis of Variance Dipyridamole / diagnostic use Electrocardiography / methods* Exercise Test / methods* Female Humans Male Middle Aged Myocardial Ischemia / diagnosis* Probability Prospective Studies Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Tomography, Emission-Computed, Single-Photon / methods* |
| Chemical | |
Reg. No./Substance:
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58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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