Document Detail


Lack of hepatotoxicity after long-term administration of cyanamide in rats: a histological and biochemical study.
MedLine Citation:
PMID:  4083036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An experimental long-term hepatotoxicity study of cyanamide in Sprague-Dawley and Wistar rats has been carried out. After six months oral administration of cyanamide (2.7 and 25 mg/kg/day) no significant histological changes have been observed in the liver. Similarly, a one year intraperitoneal administration of 8 and 16 mg/kg/day has not induced any hepatic change. Specifically, no inclusion bodies in any cyanamide treated rat have been detected. Moreover, hepatic biochemical parameters have shown no significant impairment of hepatic function at doses used in human therapy (0.5-1 mg/kg).
Authors:
R Obach; A Rives; J M Vallés; A Menargues; J Pruñonosa; J Vallés
Related Documents :
19667286 - Effect of mild and moderate liver disease on the pharmacokinetics of isavuconazole afte...
6143426 - Enzymatic changes in rat liver associated with low and high doses of a peroxisome proli...
16510356 - Flow cytometric assessment of peroxisome proliferation from frozen liver of fibrate-tre...
3214366 - Hepatotoxicity to dogs of horse meat contaminated with indospicine.
16182256 - Clozapine and haloperidol differentially alter the constitutive activity of central ser...
10824626 - Investigations of the metabolites of the trypanocidal drug melarsoprol.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta pharmacologica et toxicologica     Volume:  57     ISSN:  0001-6683     ISO Abbreviation:  Acta Pharmacol Toxicol (Copenh)     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1986-02-14     Completed Date:  1986-02-14     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370572     Medline TA:  Acta Pharmacol Toxicol (Copenh)     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  279-84     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Cyanamide / toxicity*
Cyanides / toxicity*
Drug-Induced Liver Injury / etiology*,  metabolism,  pathology
Female
Injections, Intraperitoneal
Intubation, Gastrointestinal
Liver / pathology
Liver Function Tests
Male
Rats
Rats, Inbred Strains
Sex Factors
Chemical
Reg. No./Substance:
0/Cyanides; 420-04-2/Cyanamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ion pair formation and gastrointestinal absorption of emepronium.
Next Document:  Localization of oestradiol in the rat nasal mucosa.