Document Detail


Lack of genetic association of the three more common polymorphisms of CARD15 with psoriatic arthritis and psoriasis in a German cohort.
MedLine Citation:
PMID:  15539411     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether the three common independent sequence variants of the putative pleiotropic non-MHC autoimmune gene CARD15 influence disease susceptibility in large German cohorts of patients with psoriatic arthritis and psoriasis vulgaris, before and after stratification to HLA-C. METHODS: DNA was obtained from 375 patients with psoriatic arthritis, 281 patients with psoriasis vulgaris without joint involvement, and 376 controls. The three variants of the CARD15 gene (R702W, G908R, leu1007fsinsC), and two single nucleotide polymorphisms of the HCR gene (HCR-325, HCR-2327) for HLA-C stratification were genotyped using allelic discrimination Taqman assays. RESULTS: No significant differences in genotype frequencies were observed between controls and either the psoriatic arthritis or the psoriasis vulgaris patient population, even after stratification to HLA-C in both patient cohorts, or to the type of joint involvement within the psoriatic arthritis group. CONCLUSIONS: The lack of genetic association between the most common Crohn's disease alleles of the CARD15 gene and psoriatic joint disease on large cohorts of white patients does not support a recently claimed role for CARD15 as the first non-MHC susceptibility gene in the pathogenesis of psoriatic arthritis, but confirms and extends previous studies in the case of psoriasis vulgaris.
Authors:
J Lascorz; H Burkhardt; U Hüffmeier; B Böhm; F Schürmeyer-Horst; J Lohmann; M Ständer; J Wendler; R Kelsch; C Baumann; W Küster; H Traupe; A Reis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-11-11
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  64     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-05-17     Completed Date:  2005-07-11     Revised Date:  2008-11-20    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  951-4     Citation Subset:  IM    
Affiliation:
Institute of Human Genetics, University of Erlangen-Nuremberg, Schwabachanlage 10, 91054 Erlangen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Arthritis, Psoriatic / genetics
Child
Cohort Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Intracellular Signaling Peptides and Proteins / genetics*
Middle Aged
Nod2 Signaling Adaptor Protein
Polymorphism, Genetic*
Psoriasis / genetics*
Chemical
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/NOD2 protein, human; 0/Nod2 Signaling Adaptor Protein

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