Document Detail


Lack of founding Amerindian mitochondrial DNA lineages in extinct aborigines from Tierra del Fuego-Patagonia.
MedLine Citation:
PMID:  9002668     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ancient DNA from bones and teeth of 60 individuals from four extinct human populations from Tierra del Fuego-Patagonia (Selknam, Yamana, Kaweskar and Aonikenk) has been extracted and the mitochondrial DNA (mtDNA) amplified by using the polymerase chain reaction. High-resolution analysis of endonuclease restriction site variation in the mtDNA and sequencing of its hypervariable non-coding control region, revealed complete absence of two of the four primary mitochondrial haplotype groups present in contemporary Amerinds, namely A and B. In contrast, haplogroups C and D were found in all but one sample with frequencies of approximately 38% and 60%. These results, together with the decreasing incidence of group A in more southerly latitudes in the American continent and the absence of cluster B above 55 degrees North in America and Asia, argue that the first settlers entering America 21000-14000 years ago already lacked both mtDNA lineages.
Authors:
C Lalueza; A Pérez-Pérez; E Prats; L Cornudella; D Turbón
Related Documents :
1851168 - A rapid, efficient method for purifying dna-binding proteins. denaturation-renaturation...
16939888 - Ooplasmic transfer: problems and prospects.
12140248 - A reanalysis of the ancient mitochondrial dna sequences recovered from neandertal bones.
9407318 - Selected nuclear line elements with mitochondrial-dna-like inserts are more plentiful a...
22174788 - Xpa-mediated regulation of global nucleotide excision repair by atr is p53-dependent an...
16713248 - Dna structures, repeat expansions and human hereditary disorders.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human molecular genetics     Volume:  6     ISSN:  0964-6906     ISO Abbreviation:  Hum. Mol. Genet.     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-26     Completed Date:  1997-03-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9208958     Medline TA:  Hum Mol Genet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Affiliation:
Departament de Biologia Animal, Universitat de Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Argentina
Base Sequence
DNA
DNA, Mitochondrial*
Indians, South American / genetics*
Molecular Sequence Data
Polymorphism, Genetic
Restriction Mapping
Sequence Analysis, DNA
Chemical
Reg. No./Substance:
0/DNA, Mitochondrial; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Translation initiation factor eIF-4gamma is encoded by an amplified gene and induces an immune respo...
Next Document:  A locus for autosomal dominant posterior polar cataract on chromosome 1p.