Document Detail

Lack of food anticipation in Per2 mutant mice.
MedLine Citation:
PMID:  17055980     Owner:  NLM     Status:  MEDLINE    
Predicting time of food availability is key for survival in most animals. Under restricted feeding conditions, this prediction is manifested in anticipatory bouts of locomotor activity and body temperature. This process seems to be driven by a food-entrainable oscillator independent of the main, light-entrainable clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus . Although the SCN clockwork involves self-sustaining transcriptional and translational feedback loops based on rhythmic expression of mRNA and proteins of clock genes , the molecular mechanisms responsible for food anticipation are not well understood. Period genes Per1 and Per2 are crucial for the SCN's resetting to light . Here, we investigated the role of these genes in circadian anticipatory behavior by studying rest-activity and body-temperature rhythms of Per1 and Per2 mutant mice under restricted feeding conditions. We also monitored expression of clock genes in the SCN and peripheral tissues. Whereas wild-type and Per1 mutant mice expressed regular food-anticipatory activity, Per2 mutant mice did not show food anticipation. In peripheral tissues, however, phase shifts of clock-gene expression in response to timed food restriction were comparable in all genotypes. In conclusion, a mutation in Per2 abolishes anticipation of mealtime, without interfering with peripheral synchronization by feeding cycles.
Céline A Feillet; Jürgen A Ripperger; Maria Chiara Magnone; Abdul Dulloo; Urs Albrecht; Etienne Challet
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current biology : CB     Volume:  16     ISSN:  0960-9822     ISO Abbreviation:  Curr. Biol.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-12-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9107782     Medline TA:  Curr Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2016-22     Citation Subset:  IM    
Department of Neurobiology of Rhythms, Institute of Cellular and Integrative Neurosciences, University Louis Pasteur, Centre National de la Recherche Scientifique, 67084 Strasbourg, France.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Biological Clocks / physiology*
Body Composition
Body Temperature
Cell Cycle Proteins / genetics,  metabolism*
Circadian Rhythm / physiology*
DNA Primers
Feeding Behavior / physiology*
In Situ Hybridization
Nuclear Proteins / genetics,  metabolism*
Period Circadian Proteins
Physical Exertion / physiology
Polymerase Chain Reaction
Suprachiasmatic Nucleus / metabolism,  physiology*
Transcription Factors / genetics,  metabolism*
Reg. No./Substance:
0/Cell Cycle Proteins; 0/DNA Primers; 0/Nuclear Proteins; 0/Per2 protein, mouse; 0/Period Circadian Proteins; 0/Transcription Factors
Comment In:
Curr Biol. 2006 Nov 21;16(22):R968-9   [PMID:  17113381 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Age-dependent usage of double-strand-break repair pathways.
Next Document:  Cortical responses to invisible faces: dissociating subsystems for facial-information processing.