Document Detail

Lack of evidence for endocrine disrupting effects in rats exposed to fenitrothion in utero and from weaning to maturation.
MedLine Citation:
PMID:  15590106     Owner:  NLM     Status:  MEDLINE    
Fenitrothion is a broad-spectrum organophosphate insecticide. Recently, it has been reported to exert androgenic or anti-androgenic activity in in vitro and in vivo screening assays, although the effects appear equivocal in vivo. To provide a conclusive and comprehensive evaluation of fenitrothion, especially regarding its anti-androgenic activity in the reproductive and endocrine systems, we conducted a one-generation reproductive toxicity study at appropriately toxic dose levels with a number of sensitive endpoints for endocrine disruption. Fenitrothion was administered to Crj:CD(SD)IGS parental animals (P) at concentrations of 10, 20, and 60 ppm in the diet for 10 weeks prior to mating, and throughout mating, gestation and lactation. Their offspring (F1) were exposed from weaning until maturation at the age of 10 weeks. In the P generation, brain cholinesterase activity was remarkably reduced in the 60 ppm males and in the 20 and 60 ppm females. Reproductive performance, organ weights, histopathology, and sperm analytical parameters were not affected. In the F1 generation, no general toxicity or effects on anogenital distance, retention of areolae/nipples, onset of puberty, organ weights, histopathological findings, and sperm parameters were observed. In conclusion, fenitrothion had no effects on the reproductive or endocrine systems of the P and F1 generations, even at toxic doses that markedly suppressed brain cholinesterase activity in P animals. The results suggest that fenitrothion at in-use levels in the environment is unlikely to cause disruption of human endocrine systems.
Noriko Okahashi; Masashi Sano; Kaori Miyata; Seiko Tamano; Hashihiro Higuchi; Yusuke Kamita; Takaki Seki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  206     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-02-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  17-31     Citation Subset:  IM    
Environmental Health Science Laboratory, Sumitomo Chemical Company Ltd., 3-1-98 Kasugade-naka, Konohana-ku, Osaka 554-8558, Japan.
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MeSH Terms
Acetylcholinesterase / metabolism
Administration, Oral
Brain / drug effects,  enzymology
Endocrine System / drug effects*
Fenitrothion / toxicity*
Insecticides / toxicity*
Nipples / drug effects,  growth & development
Organ Size / drug effects
Ovarian Follicle / drug effects
Prenatal Exposure Delayed Effects*
Rats, Inbred Strains
Sexual Maturation / drug effects*
Sperm Count
Sperm Motility / drug effects
Spermatozoa / cytology,  drug effects
Vagina / drug effects,  growth & development
Reg. No./Substance:
0/Insecticides; 122-14-5/Fenitrothion; EC

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