| Lack of evidence for antiatherogenic effects of wheat bran or corn bran in apolipoprotein E-knockout mice. | |
| | |
MedLine Citation:
|
PMID: 19601675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Epidemiological studies have suggested that intake of whole grains is inversely associated with coronary artery disease. The mechanisms, however, are not completely clear. We tested the hypothesis that intake of wheat bran or corn bran would (1) increase the plasma concentration of phenolic antioxidants and (2) reduce atherosclerosis in apo E-knockout mice. Apo E-knockout (E-KO) mice were fed for 18 weeks with a 0.1% cholesterol-supplemented diet in the absence of grain brans or the presence of 1.7% yellow dent corn bran or 3.3% hard red spring wheat bran. The concentration of antioxidant ferulic acid in plasma and urine was measured by HPLC to monitor the bioavailability of grain phenolics. Plasma lipoprotein profiles were determined by a combination of HPLC and online enzymatic methods. Urinary 15-isoprostane F(2t), an in vivo LDL oxidation biomarker, and atherosclerotic lesions were analyzed by ELISA and histological methods, respectively. Dietary supplementation with corn or wheat bran resulted in a 4- and 24-fold increase, respectively, in urinary excretion of ferulic acid. The urinary recovery rate of ferulic acid from the two brans in apo E-KO mice was approximately 1.9-2.9%. Dietary corn bran but not wheat bran also significantly increased the concentration of total ferulic acid in plasma. Nevertheless, the supplementation with either bran product for 18 weeks did not significantly alter the urinary excretion of 15-isoprostane F(2t), change the lipoprotein profiles, nor reduce the atherosclerotic lesion development in this animal model. The results suggest that phenolic antioxidants from the two types of bran may not be sufficient to reduce atherosclerosis in this animal model. |
| | |
Authors:
|
Zhaohui Zhao; Zuyuan Xu; Khuong Le; Nazila Azordegan; Natalie D Riediger; Mohammed H Moghadasian |
Related Documents
:
|
6244885 - Effects of diet on chemically induced bowel cancer. 821335 - Effect of bran and cholestyramine on plasma lipids in monkeys. 2171635 - The effects of sugar-beet fibre and wheat bran on iron and zinc absorption in rats. 12749345 - Importance of processing for physico-chemical and physiological properties of dietary f... 2393005 - Diet composition, energy intake, and exercise in relation to body fat in men and women. 6678755 - Paraquat concentration and renal function in mice fed purified and cereal-based diets. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of agricultural and food chemistry Volume: 57 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2009 Jul |
Date Detail:
|
Created Date: 2009-07-15 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 6455-60 Citation Subset: IM |
Affiliation:
|
Department of Human Nutritional Sciences, University of Manitoba, and Canadian Center for Agri-food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antioxidants / administration & dosage, analysis Apolipoproteins E / deficiency* Atherosclerosis / metabolism, pathology, prevention & control* Coumaric Acids / administration & dosage, blood, urine Diet Dietary Fiber / administration & dosage* Lipids / blood Lipoproteins / blood Male Mice Mice, Knockout Zea mays / chemistry* |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Apolipoproteins E; 0/Coumaric Acids; 0/Lipids; 0/Lipoproteins; 1135-24-6/ferulic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chiral separation of catechins in buckwheat groats and the effects of phenolic compounds in mice sub...
Next Document: Preventive effect of a melon extract rich in superoxide scavenging activity on abdominal and liver f...