Document Detail

Lack of enhancement of experimental photocarcinogenesis by topical retinoic acid.
MedLine Citation:
PMID:  7283473     Owner:  NLM     Status:  MEDLINE    
A controversy exists regarding the ability of retinoic acid to enhance photocarcinogenesis. Divergent results have been obtained with albino hairless mice. We examined this issue with the lightly pigmented variety. We followed two designs: 1. ultraviolet light and topical retinoic acid were given concomitantly while the retinoic acid was continued for many weeks after stopping irradiation; 2. tumors were first induced by ultraviolet light and then treated topically with retinoic acid. In both studies, retinoic acid did not enhance photocarcinogenesis with regard to latent period, tumor yield or tumor progression. It appears that different treatment schedules and different varieties of mice can produce widely disparate results.
L H Kligman; A M Kligman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of dermatological research     Volume:  270     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1981  
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  453-62     Citation Subset:  IM    
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MeSH Terms
Administration, Topical
Mice, Hairless
Neoplasms, Experimental / etiology
Neoplasms, Radiation-Induced / etiology*
Skin Neoplasms / etiology*
Tretinoin / administration & dosage,  pharmacology*
Ultraviolet Rays / adverse effects*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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