Document Detail

Lack of efficacy of topical mycophenolic acid in psoriasis vulgaris.
MedLine Citation:
PMID:  10775867     Owner:  NLM     Status:  MEDLINE    
Mycophenolic acid is effective for systemic treatment of psoriasis. However, there is no report about its topical use in this cutaneous disorder so far. We undertook a randomized, placebo-controlled, within subject comparison of mycophenolic acid 1% incorporated in an ointment base and the corresponding vehicle alone (placebo) using the psoriasis plaque test in 7 patients with plaque-type psoriasis over a period of 3 weeks. Scoring of erythema and induration was performed 3 times weekly. After 3 weeks of occlusive treatment there was a reduction of the sum score for erythema and induration in the mycophenolic acid-treated sites of 23% and of 5.7% in the vehicle-treated sites, which was not statistically significant. No adverse advents were noted during the time of study. We conclude that mycophenolic acid is ineffective when applied topically in psoriasis even under occlusion.
C C Geilen; U Mrowietz
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  42     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-05-23     Completed Date:  2000-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-40     Citation Subset:  IM    
Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany.
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MeSH Terms
Double-Blind Method
Immunosuppressive Agents / adverse effects,  therapeutic use*
Middle Aged
Mycophenolic Acid / adverse effects,  therapeutic use*
Psoriasis / drug therapy*,  pathology
Reg. No./Substance:
0/Immunosuppressive Agents; 24280-93-1/Mycophenolic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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