Document Detail


Lack of effects of fibrinogen degradation products on specific binding of [3H]spiroperidol and [3H]ADTN.
MedLine Citation:
PMID:  6889186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
No effect of fibrinogen degradation products on specific binding of [3H]spiroperidol and [3H]ADTN was observed. Low molecular weight peptides derived from fibrinogen degradation by plasmin (FDP) increase the motor activity of rats [7] augment apomorphine- and amphetamine-induced stereotypy and diminish haloperidol catalepsy [2]. It has been suggested that FDP interact with central dopamine receptor [2]. Taking the above considerations into account it was decided to investigate the effect of FDP on specific binding of [3H] spiroperidol and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene ([3H]ADTN).
Authors:
W Buczko; A De Blasi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Polish journal of pharmacology and pharmacy     Volume:  35     ISSN:  0301-0244     ISO Abbreviation:  Pol J Pharmacol Pharm     Publication Date:  1983  
Date Detail:
Created Date:  1983-10-28     Completed Date:  1983-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366561     Medline TA:  Pol J Pharmacol Pharm     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  45-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apomorphine / pharmacology
Butyrophenones / metabolism*
Dopamine / pharmacology
Fibrin Fibrinogen Degradation Products / physiology*
Male
Molecular Weight
Naphthalenes / metabolism*
Rats
Receptors, Dopamine / physiology
Spiperone / metabolism*
Tetrahydronaphthalenes / metabolism*
Chemical
Reg. No./Substance:
0/Butyrophenones; 0/Fibrin Fibrinogen Degradation Products; 0/Naphthalenes; 0/Receptors, Dopamine; 0/Tetrahydronaphthalenes; 53463-78-8/ADTN; 58-00-4/Apomorphine; 749-02-0/Spiperone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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