Document Detail


Lack of effect of salt intake on urinary uric acid excretion.
MedLine Citation:
PMID:  6834539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although it has been established that acute expansion of the extracellular fluid volume results in enhanced uric acid clearance, the effect of chronic volume expansion by a high salt diet on urinary uric acid excretion has not been examined. Eleven normal subjects were placed on a constant diet containing 10 mEq. sodium per day for 10 days, followed by 240 mEq. sodium daily for another 10 days. Measurements were performed on the final 3 days of each phase. Urinary sodium increased from 9 plus or minus 3 standard error to 221 plus or minus 9 mEq. per day (p less than 0.001), and uric acid clearance increased from 5.9 plus or minus 0.4 to 7.1 plus or minus 0.6 ml. per minute (p less than 0.01). However, serum uric acid decreased from 6.4 plus or minus 0.4 to 5.5 plus or minus 0.3 mg./dl. (p less than 0.001). Total urinary excretion of uric acid did not change (533 plus or minus 24 to 535 plus or minus 26 mg. per day). A high salt diet does not result in sustained hyperuricosuria, although it may predispose to kidney stone formation in other ways.
Authors:
N A Breslau; C Y Pak
Related Documents :
6835909 - Variation in the potassium needs of chickens selected genetically for variation in bloo...
8878379 - Factors influencing the adequacy of microencapsulation of rat pancreatic islets.
12375839 - Chemiluminescence biosensor chip based on a microreactor using carrier air flow for det...
6985799 - Fibrin membrane endowed with biological function. v. multienzyme complex of uricase, ca...
2786169 - Measurement of free radical scavengers in the spinal cord of rats with experimental aut...
7744159 - Infrared spectrometric analysis of endemic bladder stones in niger.
23333209 - Amides of 4-hydroxy-8-methanesulfonylamino-quinoline-2-carboxylic acid as zinc-dependen...
9066899 - Interlimb coordination, gait, and neural control of quadrupedalism in chimpanzees.
12653429 - Effect of menadione (vitamin k3) addition on lipid oxidation and tocopherols content in...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of urology     Volume:  129     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1983 Mar 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  531-2     Citation Subset:  AIM; IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Calcium / metabolism
Extracellular Space
Female
Humans
Kidney Calculi / etiology
Male
Sodium Chloride / pharmacology*
Uric Acid / urine*
Grant Support
ID/Acronym/Agency:
M01-RR00633/RR/NCRR NIH HHS; P50-AM20543/AM/NIADDK NIH HHS; R01 AM16061/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
69-93-2/Uric Acid; 7440-70-2/Calcium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Radical prostatectomy incontinence and the AS791 artificial urinary sphincter.
Next Document:  Filling of the obturator nodes in pedal lymphangiography: fact or fiction.