Document Detail

Lack of effect of insulin in hepatocytes isolated from streptozotocin-diabetic male rats.
MedLine Citation:
PMID:  2967704     Owner:  NLM     Status:  MEDLINE    
Diabetes mellitus is known to affect drug and steroid metabolism in the rat liver. Recently we have demonstrated that in-vitro insulin addition to hepatocytes obtained from normal male rats showed a significant dose-related increase in androstenedione metabolism. We have extended our study this time by using 3- and 21-days streptozotocin (STZ) diabetic and insulin-treated STZ-diabetic male rats. Hepatocytes from 3- and 21-days STZ-diabetic rats were resistant to the effect of insulin while insulin-treated diabetic rats indicated partial restoration of insulin effect. Since insulin resistance is a characteristic feature of type II diabetes mellitus, we would like to suggest that STZ-diabetic rats may be a model for type II diabetes mellitus.
A H Hussin; P Skett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical pharmacology     Volume:  37     ISSN:  0006-2952     ISO Abbreviation:  Biochem. Pharmacol.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-06-30     Completed Date:  1988-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0101032     Medline TA:  Biochem Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1683-6     Citation Subset:  IM    
Department of Pharmacology, The University, Glasgow, Scotland, U.K.
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MeSH Terms
Androstenedione / metabolism*
Diabetes Mellitus, Experimental / physiopathology*
Diabetes Mellitus, Type 2 / physiopathology*
Insulin / pharmacology*
Liver / physiopathology*
Steroid Hydroxylases / metabolism
Reg. No./Substance:
11061-68-0/Insulin; 18883-66-4/Streptozocin; 63-05-8/Androstenedione; EC 1.14.-/Steroid Hydroxylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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