Document Detail

Lack of effect of increased pineal serotonin content on H3-tryptophan uptake.
MedLine Citation:
PMID:  240913     Owner:  NLM     Status:  MEDLINE    
Major increases in the serotonin concentrations of rat pineal organs were produced by administering Catron, a monoamine oxidase inhibitor, prior to autopsy, or by preincubating the glands with serotonin (3X10-4M). These increases had no effect on pineal uptake of H3-tryptophan, the amino acid precursor for serotonin. These observations provide further evidence that the control of serotonin synthesis involves an important "open-loop" component.
R J Wurtman; H M Shein
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neural transmission     Volume:  36     ISSN:  -     ISO Abbreviation:  J. Neural Transm.     Publication Date:  1975  
Date Detail:
Created Date:  1975-12-11     Completed Date:  1975-12-11     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0337042     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  177-81     Citation Subset:  IM    
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MeSH Terms
Hydrazines / pharmacology
Pineal Gland / drug effects,  metabolism*
Serotonin / metabolism*
Tryptophan / metabolism*
Reg. No./Substance:
0/Hydrazines; 333DO1RDJY/Serotonin; 8DUH1N11BX/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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