Document Detail

Lack of effect of fluoxetine on the hypoprothrombinemic response of warfarin.
MedLine Citation:
PMID:  10950474     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to assess the effect of fluoxetine on the hypoprothrombinemic response of warfarin in patients chronically anticoagulated. Patients receiving low-intensity anticoagulation with warfarin were recruited. All patients were taking stable dosages of warfarin and had two baseline prothrombin times (PTs) within 10% of each other. Each patient received fluoxetine (20 mg daily) for 21 days. PTs were measured on days 2, 5, 8, 12, 15, 19, and 22 of fluoxetine administration. Six patients completed the study. There was no significant difference in mean PTs before and during fluoxetine administration. Fluoxetine at the dosage studied does not predictably effect the hypoprothrombinemic response of warfarin.
M A Ford; M L Anderson; J P Rindone; D W Jaskar
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  17     ISSN:  0271-0749     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  1997 Apr 
Date Detail:
Created Date:  2000-09-05     Completed Date:  2000-09-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  110-2     Citation Subset:  IM    
Veterans Affairs Medical Center, Tucson, Arizona, USA.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Anticoagulants / pharmacokinetics*
Drug Interactions
Fluoxetine / pharmacokinetics*
Hypoprothrombinemias / chemically induced
Middle Aged
Prothrombin Time*
Serotonin Uptake Inhibitors / pharmacokinetics*
Warfarin / pharmacokinetics*
Reg. No./Substance:
0/Anticoagulants; 0/Serotonin Uptake Inhibitors; 54910-89-3/Fluoxetine; 81-81-2/Warfarin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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