| Lack of effect of fever on antipyrine oxidation in the rat. | |
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MedLine Citation:
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PMID: 658126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The pharmacokinetics of 14C-antipyrine were studied in rats with fever induced by intracerebroventricular injections of prostaglandin E1. The rats were used as their own controls with at least 5 days between the control and the fever period. The effect of temperature on rates of antipyrine metabolism (oxidation followed by conjugation) and paracetamol metabolism (conjugation) was also tested in suspensions of isolated liver cells. Fever increased the biological half-life of antipyrine to 147% of control values (P less than 0.01) and the apparent volume of distribution to 113% of control values (P less than 0.05). In individual rats the increase in biological half-life was most counterbalanced by the increase in apparent volume of distribution, resulting in non-significant changes in the metabolic clearance of the drug. The half-life of antipyrine elimination in suspensions of isolated liver cells was not changed by increasing the temperature from 29 to 39 degrees C. The half-life of paracetamol elimination in suspensions of isolated liver cells decreased, however, when the temperature was increased from 29 to 39 degrees C. The results suggest that antipyrine oxidation was not influenced by temperature changes in the range of moderate fever and that temperature changes affected different types of metabolic reactions differently. |
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Authors:
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J Aarbakke; G Gadeholt; H Olsen |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: European journal of pharmacology Volume: 49 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-08-14 Completed Date: 1978-08-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 31-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipyrine / metabolism* Body Temperature / drug effects Fever / chemically induced, metabolism* Injections, Intraventricular Kinetics Liver / metabolism Male Models, Biological Oxidation-Reduction Prostaglandins E / administration & dosage, pharmacology Rats |
| Chemical | |
Reg. No./Substance:
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0/Prostaglandins E; 60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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