Document Detail


Lack of effect of estrogen on rest and treadmill exercise in postmenopausal women without known cardiac disease.
MedLine Citation:
PMID:  9315595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To assess the peripheral vascular effects of estrogen in women without coronary disease, normal postmenopausal women (mean age 56 +/- 8 years) participated in a randomized, crossover trial using treadmill exercise echocardiography, and received oral conjugated estrogen, 0.625 mg/day or underwent a drug-free period. There was no significant effect on heart rate, blood pressure, double product, left ventricular end-systolic and end-diastolic diameters, or electrocardiographic measures after estrogen. In contrast to the profound effects reported in patients with cardiac disease, oral estrogen in normal women does not bestow significant benefit on treadmill exercise echocardiographic variables at rest or during modest levels of exercise.
Authors:
M Lee; E G Giardina; S Homma; M R DiTullio; R R Sciacca
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  80     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-21     Completed Date:  1997-10-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  793-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, College of Physicians & Surgeons, Columbia University, New York, New York 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cross-Over Studies
Echocardiography
Electrocardiography / drug effects
Estradiol / blood
Estrogens, Conjugated (USP) / pharmacology*
Exercise Test / drug effects*
Female
Hemodynamics / drug effects*
Humans
Middle Aged
Postmenopause / drug effects*,  physiology
Rest
Single-Blind Method
Grant Support
ID/Acronym/Agency:
HL-07406/HL/NHLBI NIH HHS; RR-00645/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Estrogens, Conjugated (USP); 50-28-2/Estradiol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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