Document Detail


Lack of effect of cimetidine on action of phenprocoumon.
MedLine Citation:
PMID:  7173307     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In patients on oral warfarin, nicoumalone and phenindione an increase in the anticoagulant effect has been described during concomitant treatment with cimetidine. Therefore the effect of cimetidine on the steady state dynamics of phenprocoumon has been investigated in ten outpatients. No change in the anticoagulant effect of phenprocoumon was observed during or after two weeks on cimetidine, as measured by the thrombotest coagulation method, prothrombin time, fibrinopeptide A concentration and plasma phenprocoumon level. The data show that cimetidine does not interact with the metabolism of phenprocoumon in contrast to warfarin. Thus, phenprocoumon maintenance therapy when combined with concomitant cimetidine treatment can be considered not to carry an increased risk of haemorrhagic complications.
Authors:
J Harenberg; R Zimmermann; C Staiger; J X de Vries; E Walter; E Weber
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  23     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1982 Oct 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  365-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
4-Hydroxycoumarins / pharmacology*
Biotransformation
Cimetidine / metabolism,  pharmacology*
Drug Administration Schedule
Guanidines / pharmacology*
Humans
Partial Thromboplastin Time
Phenprocoumon / metabolism,  pharmacology*
Prothrombin Time
Chemical
Reg. No./Substance:
0/4-Hydroxycoumarins; 0/Guanidines; 435-97-2/Phenprocoumon; 51481-61-9/Cimetidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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