Document Detail

Lack of effect of the alpha-adrenergic agonist clonidine on pulsatile luteinizing hormone secretion in a double blind study in men.
MedLine Citation:
PMID:  2642486     Owner:  NLM     Status:  MEDLINE    
This study was designed to evaluate the effects of alpha-adrenergic stimulation on the hypothalamic LHRH pulse generator in men. In 10 normal men, venous blood was sampled on 2 occasions at 10-min intervals for 8 h, beginning 30 min after oral administration of either placebo or 0.3 mg clonidine according to a randomized double blind protocol. Compared to placebo, clonidine induced a marked release of GH (P less than 0.0001 for response areas under the curve after placebo and clonidine), a fall in systolic and diastolic blood pressure and in heart rate (P less than 0.002 for areas under the curve after placebo and clonidine), and feelings of sedation and dry mouth (P less than 0.002 and P less than 0.05 for areas under the cumulative scores for changes in alertness and salivation, respectively). There was no difference between the results obtained after placebo and clonidine for the mean number of LH pulses [3.3 +/- 0.4 (+/- SE) and 3.3 +/- 0.3 pulses/8 h], for the mean amplitude of all LH pulses (3.8 +/- 0.4 and 4.1 +/- 0.5 IU/L), or for the areas under the LH concentration-time curve (2741 +/- 251 and 2728 +/- 215 IU/L.min). The lack of effect of clonidine on LH secretion at a dose that effectively induced GH secretion and other centrally mediated effects indicates that the actions of testosterone and opiates to decelerate the frequency of the LHRH pulse generator in men are not mediated by diminished alpha-adrenergic stimulation. From these results, taken together with previous data, we conclude that alpha-adrenergic systems do not play a major role in the regulation of episodic LH release in men.
J M Kaufman; A Vermeulen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  68     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-22     Citation Subset:  AIM; IM    
Department of Endocrinology, University Hospital Ghent, Belgium.
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MeSH Terms
Blood Pressure / drug effects
Clinical Trials as Topic
Clonidine / pharmacology*
Double-Blind Method
Gonadotropin-Releasing Hormone / antagonists & inhibitors
Growth Hormone / blood
Heart Rate / drug effects
Hypothalamus / drug effects,  metabolism
Luteinizing Hormone / blood*,  secretion
Random Allocation
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 4205-90-7/Clonidine; 9002-67-9/Luteinizing Hormone; 9002-72-6/Growth Hormone

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