Document Detail


Lack of effect of Lactobacillus GG in breast-fed infants with rectal bleeding: a pilot double-blind randomized controlled trial.
MedLine Citation:
PMID:  17667723     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: For breast-fed infants with rectal bleeding, maternal restriction of dietary protein such as cow's milk proteins is often recommended; however, poor response to dietary protein restriction is of concern. This pilot study was designed to assess the effectiveness of Lactobacillus GG (LGG) in breast-fed infants with rectal bleeding. PATIENTS AND METHODS: Breast-fed infants <6 months of age with rectal bleeding (defined as the presence of visible specks or streaks of blood mixed with mucus in the stool in otherwise healthy infants) were enrolled in a double-blind randomized controlled trial in which they received LGG 3 x 10 colony-forming units (n = 14) or placebo (n = 15) twice daily for 4 weeks as an adjunct to cow's milk restriction in the mother's diet. Analyses were based on allocated treatment and included data from 26 infants. RESULTS: Mean duration of rectal bleeding was similar in the LGG and control groups (17.3 +/- 10.6 vs 15.4 +/- 11 days; mean difference -1.9 (95% confidence interval [CI] -4 to 7). No difference was found in the number of infants with clinical resolution of rectal bleeding within 72 hours and no relapse afterward (2/11 vs 3/15, relative risk [RR] 0.9, 95% CI 0.2-3.9) and the number of infants with clinical resolution of rectal bleeding within 72 hours followed by relapse of symptoms (5/11 vs 5/15, RR 1.4, 95% CI 0.5-3.5). Breast-feeding cessation was not needed in any infant. CONCLUSIONS: These results do not support the use of LGG as an adjunct to maternal cow's milk restriction in breast-fed infants with rectal bleeding.
Authors:
H Szajewska; A Gawronska; H Wos; A Banaszkiewicz; U Grzybowska-Chlebowczyk
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  45     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-01     Completed Date:  2007-09-20     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  IM    
Affiliation:
Second Department of Pediatrics, Medical University of Warsaw, Warsaw, Poland. hania@ipgate.pl
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MeSH Terms
Descriptor/Qualifier:
Breast Feeding
Confidence Intervals
Double-Blind Method
Female
Gastrointestinal Hemorrhage / epidemiology,  etiology,  therapy*
Humans
Infant
Infant, Newborn
Lactobacillus rhamnosus / physiology*
Male
Maternal Nutritional Physiological Phenomena*
Milk Hypersensitivity / complications*
Milk Proteins / administration & dosage,  adverse effects,  immunology
Odds Ratio
Pilot Projects
Probiotics*
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Milk Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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