| Lack of dehydroepiandrosterone effect on a combined endurance and resistance exercise program in postmenopausal women. | |
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MedLine Citation:
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PMID: 18029465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Recent studies disputed the widely promoted anti-aging effect of dehydroepiandrosterone (DHEA) supplementation; however, conflicting data exist on whether physiological DHEA supplementation enhances exercise training effects on body composition, physical performance, and cardiometabolic risk in healthy postmenopausal women. OBJECTIVE: The aim of this study was to determine whether 12 wk of DHEA supplementation (50 mg/d) in postmenopausal women enhances exercise-related changes in body composition, physical performance, and cardiometabolic risk. DESIGN AND SETTING: This study was a 12-wk randomized double-blind, placebo-controlled trial and took place at the Mayo Clinic General Clinical Research Center (Rochester, MN). PARTICIPANTS: Thirty-one sedentary, postmenopausal, Caucasian women (mean +/- sem age 64.6 +/- 1.0 yr) completed the study. INTERVENTION: Participants were randomized to one of two 12-wk interventions: 1) exercise training plus 50 mg/d of DHEA (n = 17), or 2) exercise training plus placebo (n = 14). The exercise intervention consisted of both endurance (4 d/wk) and resistance (3 d/wk) exercise components. MAIN OUTCOME MEASURES: The main outcomes were measures of body composition, physical performance, and measures of cardiometabolic risk. RESULTS: DHEA treatment with exercise resulted in increases in circulating sulfated DHEA (650%), total testosterone (100%), estradiol (165%), estrone (85%), and IGF-I (30%) (all P < or = 0.05, for all within and between treatment comparisons). Although exercise training alone significantly improved physical performance, body composition, and insulin sensitivity, administration of DHEA provided no additional benefits. CONCLUSIONS: Twelve weeks of combined endurance and resistance training significantly improved body composition, physical performance, insulin sensitivity, and low-density lipoprotein cholesterol particle number and size, whereas DHEA had no additional benefits. |
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Authors:
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Ada Igwebuike; Brian A Irving; Maureen L Bigelow; Kevin R Short; Joseph P McConnell; K Sreekumaran Nair |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural Date: 2007-11-20 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 93 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-08 Completed Date: 2008-04-10 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 534-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Endocrinology, Endocrine Research Unit, Mayo Clinic, 200 First Street SW, Joseph 5-194, Rochester, Minnesota 55905, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Glucose / metabolism Body Composition / drug effects, physiology Cholesterol / blood Dehydroepiandrosterone / blood, pharmacology* Dehydroepiandrosterone Sulfate / blood Double-Blind Method Estradiol / blood Estrone / blood Female Glucose Clamp Technique Humans Insulin Resistance / physiology Insulin-Like Growth Factor I / metabolism Middle Aged Physical Endurance / drug effects*, physiology Physical Fitness / physiology* Postmenopause / blood, physiology* Testosterone / blood Triglycerides / blood |
| Grant Support | |
ID/Acronym/Agency:
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1 UL1 RR24150-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Triglycerides; 50-28-2/Estradiol; 53-16-7/Estrone; 53-43-0/Dehydroepiandrosterone; 57-88-5/Cholesterol; 58-22-0/Testosterone; 651-48-9/Dehydroepiandrosterone Sulfate; 67763-96-6/Insulin-Like Growth Factor I |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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