| Lack of correlation between short-term dynamics of diabetic retinopathy lesions and the arterial blood pressure. | |
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MedLine Citation:
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PMID: 20890776 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Diabetic retinopathy is characterized by morphological lesions in the ocular fundus related to impairment of the retinal blood flow. The morphological lesions display a dynamic pattern of new formation and resorption of lesions, with a turn-over within days to weeks that may reflect basic pathophysiological mechanisms underlying the disease. However, a possible relationship between short-term fluctuations in diabetic retinopathy and risk factors for the long-term prognosis of diabetic retinopathy, such as the arterial blood pressure, has not been investigated. METHODS: Five patients with moderate non-proliferative diabetic retinopathy were examined by fundus photography and measurement of the blood pressure at 1- to 2-week intervals for up to 1 year. The numbers of microaneurysms/haemorrhages and hard exudates in the macular area were counted, and changes in these counts were related to changes in the arterial blood pressure. RESULTS: The five patients discontinued the study after 1-12 months, which resulted in between 5 and 39 examinations per patient, and amounted to a total of 101 examinations. There was a significant covariation between microaneurysms/haemorrhages and hard exudates, whereas there was no significant covariation between the number of either type of lesion and the blood pressure. CONCLUSIONS: The cause of dynamic changes in diabetic retinopathy lesions occurring over days to weeks may involve other factors than changes in the arterial blood pressure. |
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Authors:
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Toke Bek |
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Publication Detail:
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Type: Journal Article Date: 2010-10-03 |
Journal Detail:
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Title: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie Volume: 249 ISSN: 1435-702X ISO Abbreviation: Graefes Arch. Clin. Exp. Ophthalmol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8205248 Medline TA: Graefes Arch Clin Exp Ophthalmol Country: Germany |
Other Details:
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Languages: eng Pagination: 267-71 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology, Århus University Hospital, DK-8000, Århus C, Denmark, toke.bek@mail.tele.dk. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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