Document Detail

Lack of correlation between microalbuminuria and endothelial function in essential hypertensive patients.
MedLine Citation:
PMID:  8586817     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate whether microalbuminuria, defined as urinary albumin excretion between 30 and 300 mg/24 h, is associated with endothelial dysfunction in essential hypertensive patients. DESIGN: We correlated urinary albumin excretion with vasodilatation in response to endothelium-dependent (acetylcholine) and -independent (sodium nitroprusside) agonists in the forearm vascular bed in essential hypertensive patients with (n = 13) and without (n = 23) microalbuminuria and matched normotensive controls (n = 21). METHOD: We studied forearm vascular responses (strain-gauge plethysmography) to intrabrachial infusion of acetylcholine (0.15, 0.45, 1.5, 4.5 and 15 ng/100 ml forearm tissue/min) and of sodium nitroprusside (1, 2, 4ng/100 ml forearm tissue per min). Minimal forearm vascular resistances (the ratio between mean arterial pressure and maximal forearm vasodilation induced by 13 min of ischaemia + 1 min of exercise) were also evaluated. RESULTS: Responses to acetylcholine, but not to sodium nitroprusside, were significantly blunted and minimal forearm vascular resistances were increased in hypertensive patients compared with controls. However, no correlation was found between urinary albumin excretion and vasodilatation in response to acetylcholine or to sodium nitroprusside or between urinary albumin excretion and minimal forearm vascular resistances. CONCLUSIONS: In hypertensive patients, increased urinary albumin excretion is associated neither with functional nor with structural dysfunction in the forearm vasculature.
S Taddei; A Virdis; P Mattei; L Ghiadoni; I Sudano; P Arrighi; A Salvetti
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  13     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-27     Completed Date:  1996-03-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1003-8     Citation Subset:  IM    
I Clinica Medica, Cattedra di Medicina Interna, University of Pisa, Italy.
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MeSH Terms
Acetylcholine / pharmacology
Albuminuria / drug therapy,  etiology,  physiopathology*
Blood Pressure
Dose-Response Relationship, Drug
Endothelium, Vascular / drug effects,  physiopathology*
Forearm / blood supply
Hypertension / complications,  drug therapy,  physiopathology*
Infusions, Intra-Arterial
Middle Aged
Nitroprusside / pharmacology
Vascular Resistance
Vasodilator Agents / pharmacology
Reg. No./Substance:
0/Vasodilator Agents; 15078-28-1/Nitroprusside; 51-84-3/Acetylcholine

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