| Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration. | |
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MedLine Citation:
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PMID: 15921384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 58 patients with transfusion dependent anemia, we compared cardiac function, as assessed by gated pooled cardiac scan at rest and during exercise stress, with liver iron concentrations (LIC) as determined by adequate biopsy samples. There was no relationship between LIC and cardiac function and deaths occurred in patients with LIC levels below those that are usually associated with cardiac death. LIC should not be used as a surrogate to determine risk of cardiac complications but purely for management of the hepatic iron load. Other methods, particularly magnetic resonance imaging, should be used to assess cardiac iron overload. |
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Authors:
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Vasili Berdoukas; Carolyn Dakin; Anthony Freema; Ian Fraser; Athanassios Aessopos; Timothy Bohane |
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Publication Detail:
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Type: Letter |
Journal Detail:
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Title: Haematologica Volume: 90 ISSN: 1592-8721 ISO Abbreviation: Haematologica Publication Date: 2005 May |
Date Detail:
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Created Date: 2005-05-30 Completed Date: 2007-11-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0417435 Medline TA: Haematologica Country: Italy |
Other Details:
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Languages: eng Pagination: 685-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anemia, Diamond-Blackfan / complications, therapy Anemia, Sickle Cell / complications, therapy Biological Markers Biopsy, Needle Blood Transfusion / adverse effects Child Female Gated Blood-Pool Imaging Heart Diseases / etiology*, physiopathology, radionuclide imaging Humans Iron / analysis* Iron Overload / complications*, etiology, pathology Liver / chemistry*, pathology Magnetic Resonance Imaging Male Middle Aged Thalassemia / complications, therapy |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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