Document Detail

Lack of correlation between iron overload cardiac dysfunction and needle liver biopsy iron concentration.
MedLine Citation:
PMID:  15921384     Owner:  NLM     Status:  MEDLINE    
In 58 patients with transfusion dependent anemia, we compared cardiac function, as assessed by gated pooled cardiac scan at rest and during exercise stress, with liver iron concentrations (LIC) as determined by adequate biopsy samples. There was no relationship between LIC and cardiac function and deaths occurred in patients with LIC levels below those that are usually associated with cardiac death. LIC should not be used as a surrogate to determine risk of cardiac complications but purely for management of the hepatic iron load. Other methods, particularly magnetic resonance imaging, should be used to assess cardiac iron overload.
Vasili Berdoukas; Carolyn Dakin; Anthony Freema; Ian Fraser; Athanassios Aessopos; Timothy Bohane
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  Haematologica     Volume:  90     ISSN:  1592-8721     ISO Abbreviation:  Haematologica     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-30     Completed Date:  2007-11-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417435     Medline TA:  Haematologica     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  685-6     Citation Subset:  IM    
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MeSH Terms
Anemia, Diamond-Blackfan / complications,  therapy
Anemia, Sickle Cell / complications,  therapy
Biological Markers
Biopsy, Needle
Blood Transfusion / adverse effects
Gated Blood-Pool Imaging
Heart Diseases / etiology*,  physiopathology,  radionuclide imaging
Iron / analysis*
Iron Overload / complications*,  etiology,  pathology
Liver / chemistry*,  pathology
Magnetic Resonance Imaging
Middle Aged
Thalassemia / complications,  therapy
Reg. No./Substance:
0/Biological Markers; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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