| Lack of correlation between cortical levels of choline acetyltransferase and learning scores in rats with globus pallidus lesions. | |
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MedLine Citation:
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PMID: 3697716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous work has shown that rats with lesions of the globus pallidus (GP) exhibit a generalized learning impairment. Data are presented suggesting that this impairment is not due to inadvertent damage to the nucleus basalis magnocellularis. Rats with GP lesions evidenced a significant visual discrimination learning loss and a significant reduction in cortical choline acetyltransferase (ChAT) activity. However, there was no significant correlation between the severity of the learning loss and the amount of reduction of cortical ChAT activity. |
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Authors:
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R Thompson; R B Gibbs; G A Ristic; C W Cotman; J Yu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Brain research Volume: 367 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1986 Mar |
Date Detail:
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Created Date: 1986-06-09 Completed Date: 1986-06-09 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 402-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Basal Ganglia Diseases / complications, enzymology Choline O-Acetyltransferase / metabolism* Discrimination Learning Globus Pallidus* Learning Disorders / enzymology*, etiology Male Rats Rats, Inbred Strains Visual Perception |
| Chemical | |
Reg. No./Substance:
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EC 2.3.1.6/Choline O-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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