Document Detail

Lack of correlation between cardiac mass and arteriolar structural changes in mild-to-moderate hypertension.
MedLine Citation:
PMID:  1663974     Owner:  NLM     Status:  MEDLINE    
A morphological restructuring of cardiac and arteriolar tissue is common in hypertension. The parallel evolution of these two processes as a compensatory response to pressure overload is a frequently assumed but unsubstantiated hypothesis. To evaluate this possibility, we have concomitantly measured left ventricular mass (LVM; two-dimensional echo) and minimal forearm vascular resistance (FVR; derived from the ratio of intra-arterial blood pressure: forearm blood flow by venous plethysmography) at maximal postischemic (13 min ischemia + 1 min hand exercise) reactive hyperemia. The study was performed on 29 essential hypertensive patients (15 males, 14 females, aged 50 +/- 10 years) who had not been undergoing treatment for hypertension for at least 15 days at the time of study. Minimum FVR was taken as a hemodynamic index of the integrated arteriolar lumen at the forearm level. LVM index and minimum FVR ranged from normal to clearly altered values. In spite of a wide spread of values, no correlation existed between the individual values of the two variables. Systemic mean blood pressure correlated with minimum FVR and tended to correlate with LVMI. Thus, morphological restructing of cardiac and arteriolar tissue does not seem to evolve in parallel in human hypertension. Pressure overload may contribute to cardiovascular hypertrophy, but other unrelated mechanisms may also underlie the development of cardiac and arteriolar abnormalities of human hypertension.
A R Lucarini; M Spessot; E Picano; C Marini; F Lattanzi; R Pedrinelli; A Salvetti
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  9     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-03-12     Completed Date:  1992-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1187-91     Citation Subset:  IM    
Clinica Medica I, Hypertension Unit, Pisa, Italy.
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MeSH Terms
Arterioles / pathology
Cardiomegaly / etiology*,  ultrasonography
Forearm / blood supply
Hypertension / complications*,  physiopathology,  ultrasonography
Middle Aged
Vascular Resistance / physiology*
Ventricular Function, Left / physiology

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