Document Detail

Lack of circulating bioactive and immunoreactive IGF-I changes despite improved fitness in chronic kidney disease patients following 48weeks of physical training.
MedLine Citation:
PMID:  21251861     Owner:  NLM     Status:  Publisher    
OBJECTIVE: As known abnormalities exist in the insulin-like growth factor (IGF) system in chronic kidney disease (CKD) patients, the measurement of bioactive IGF-I may provide further insight into the therapeutic potential of long-term exercise training. DESIGN: Patients (N=21) with stages 3 and 4 CKD were recruited from a local nephrology practice in Springfield, MA and randomized into matched treatment and control groups. The treatment group participated in 48weeks of supervised, progressive exercise training and dietary counseling, while the control group received only usual care. Treadmill testing, anthropometric measurements, and blood samples for analysis of immunoreactive IGF-I, IGF-II, IGFBP-1 and -2, and bioactive IGF-I were taken at baseline, 24weeks, and 48weeks. RESULTS: There were no significant differences in any of the components of the IGF system (all p-values>0.05). Immunoreactive IGF-I levels correlated significantly with bioactive IGF-I at baseline (r=0.50, p=0.02) and at 48weeks (r=0.64, p=0.01). There was a significant interaction between group and time for both V̇O(2peak) (p=0.03) and total treadmill time (TT) (p<0.01). CONCLUSIONS: Despite improvements in physical performance, a 48-week training program did not affect any of the circulating IGF system measurements. Disparities between these findings and those of other researchers reporting a biphasic response to long-term training may be explained by differences in study groups and exercise programs.
Sara M Gregory; Samuel A Headley; Michael Germain; Allan Flyvbjerg; Jan Frystyk; Mary Ann Coughlin; Charles M Milch; Sheila Sullivan; Bradley C Nindl
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-18
Journal Detail:
Title:  Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society     Volume:  -     ISSN:  1532-2238     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814320     Medline TA:  Growth Horm IGF Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Growth Hormone Research Society. Published by Elsevier Ltd. All rights reserved.
Exercise Science Program, Department of Exercise Science and Sports Studies, Springfield College, Springfield, MA 01109, USA.
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