Document Detail


Lack of circadian variation in the sensitivity of rat terminal 5-HT1B autoreceptors.
MedLine Citation:
PMID:  8083808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The sensitivity of terminal 5-HT1B autoreceptors in the cerebral cortex and hippocampus to both agonist and antagonist was determined at four different time points in the light:dark cycle of the rat to evaluate whether changes in their responsiveness underlie the circadian rhythm in 5-hydroxytryptamine (5-HT) release. No significant circadian differences were evident in the apparent pIC50 values calculated for 5-HT to inhibit K(+)-evoked tritium efflux or in the apparent pA2 values calculated for methiothepin to antagonize the effect of 5-HT, at the different time points, in either brain region. These findings suggest that the sensitivity of terminal 5-HT1B autoreceptors in rat cerebral cortex and hippocampus does not change in a circadian pattern, during the light:dark cycle, and argues against such a change influencing the circadian variation in 5-HT release.
Authors:
A Singh; P Redfern
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pharmacy and pharmacology     Volume:  46     ISSN:  0022-3573     ISO Abbreviation:  J. Pharm. Pharmacol.     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-10-13     Completed Date:  1994-10-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376363     Medline TA:  J Pharm Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  366-70     Citation Subset:  IM    
Affiliation:
Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, Avon, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cerebral Cortex / drug effects,  metabolism
Circadian Rhythm*
Dose-Response Relationship, Drug
Hippocampus / drug effects,  metabolism
Light
Male
Potassium / pharmacology
Rats
Rats, Wistar
Receptors, Serotonin / drug effects*,  metabolism
Serotonin Agonists / pharmacology*
Serotonin Antagonists / pharmacology*
Chemical
Reg. No./Substance:
0/Receptors, Serotonin; 0/Serotonin Agonists; 0/Serotonin Antagonists; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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