Document Detail

Lack of casual relationship between medullary blood congestion and tubular necrosis in postischaemic kidney damage.
MedLine Citation:
PMID:  3630721     Owner:  NLM     Status:  MEDLINE    
The effect of haemodilution on medullary blood congestion and tubular necrosis was investigated in the rat kidney. Male Sprague-Dawley rats were subjected to 60 min of unilateral, kidney ischaemia and 24 h of reperfusion. Haemodilution was performed by replacing blood by homologous serum and was done either before induction of ischaemia or during the ischaemic period. Cellular necrosis was evaluated morphologically by a histochemical staining for calcium and a dye-exclusion test. Trapped erythrocytes were visualized by the DAB reaction. It was found that haemodilution could totally prevent medullary congestion. In spite of this, the extent and distribution of necrotic tubular cells in the outer stripe of the outer medulla were the same whether the animal was subjected to haemodilution or not. Our results strongly suggest that the cellular necrosis and the medullary congestion are two separate phenomena occurring at the same time, but without a causal relationship to each other.
G Andersson; E Jennische
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  130     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-09-29     Completed Date:  1987-09-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  429-32     Citation Subset:  IM    
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MeSH Terms
Ischemia / complications*
Kidney / blood supply*,  pathology
Kidney Failure, Acute / etiology*,  physiopathology
Kidney Medulla / physiopathology*
Kidney Tubules / pathology*
Rats, Inbred Strains
Renal Circulation

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