| Lack of carcinogenicity of gardenia blue colour given chronically in the diet to F344 rats. | |
| | |
MedLine Citation:
|
PMID: 10722884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The carcinogenicity of gardenia blue colour was examined in Fischer 344 (F344) rats. Groups of 50 males and 50 females were given the material at dietary doses of 0 (control), 2.5 or 5% for 104 weeks and then sacrificed. The doses were selected on the basis of results from a 13-week subchronic toxicity study. A slight increase in relative organ weights of the left lung was observed in male rats of the 5% group. However, no significant differences between the control and treated groups were noted with regard to clinical signs, mortality and haematological findings. A variety of tumours developed in all groups, including the controls, but all were histologically similar to those known to occur spontaneously in F344 rats, and no statistically significant increase in the incidence of any type of neoplastic lesion was found for either sex in the treated groups. Thus, it was concluded that, under the present experimental conditions, gardenia blue colour is not carcinogenic in F344 rats. |
| | |
Authors:
|
T Imazawa; A Nishikawa; F Furukawa; K Kasahara; T Ikeda; M Takahashi; M Hirose |
Related Documents
:
|
18932044 - Low-dose continuous 5-fluorouracil infusion stimulates vegf-a-mediated angiogenesis. 7585454 - Linear relationship between flux density and tumor co-promoting effect of prolonged mag... 20614104 - Hepatocellular hypertrophy and cell proliferation in sprague-dawley rats following diet... 3457204 - Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene. 1786564 - Behavioral sensitization to cocaine is not associated with changes in serotonin (5-ht) ... 16180084 - Melatonin increases the survival time of animals with untreated mammary tumours: neuroe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: 38 ISSN: 0278-6915 ISO Abbreviation: Food Chem. Toxicol. Publication Date: 2000 Apr |
Date Detail:
|
Created Date: 2000-06-02 Completed Date: 2000-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 313-8 Citation Subset: IM |
Affiliation:
|
Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo, Japan. imazawa@nihs.go.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Oral Animals Blood / drug effects Body Weight / drug effects Carcinogenicity Tests Dose-Response Relationship, Drug Female Glucosides / administration & dosage, chemistry, toxicity* Iridoids Male Neoplasms, Experimental / chemically induced Organ Size / drug effects Plant Extracts Pyrans / administration & dosage, chemistry, toxicity* Rats Rats, Inbred F344 Survival Rate |
| Chemical | |
Reg. No./Substance:
|
0/Gardenia blue color; 0/Glucosides; 0/Iridoids; 0/Plant Extracts; 0/Pyrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Understanding the functions of kinesin-II.
Next Document: Lack of oestrogenic effects of food preservatives (parabens) in uterotrophic assays.