| Lack of burning and stinging from a novel first-aid formulation applied to experimental wounds. | |
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MedLine Citation:
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PMID: 15131727 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Antiseptic-anesthetic first aid formulations typically produce a burning or stinging sensation when used on wounds. The aim of this study was to assess the lack of sting/burn potential of a prototype first-aid wipe when applied to superficial wounds. This was a one-day, double-blind, randomized study, evaluating the stinging/burning sensation from a prototype first-aid wipe with a cellulose base containing 1.0% pramoxine HCL and 0.13% benzalkonium chloride. The study followed a direct comparison test design of four test formulations. The remaining three articles were: (a) sterile 0.9% sodium chloride (no-sting/no-burn control), (b) 3% hydrogen peroxide (first-aid sting/burn control), and (c) 70% isopropyl alcohol (second sting/burn control). The test was performed on 24 subjects. The tape stripping method was used to create four standardized wounds on the volar forearms, reaching the glistening layer. Each test article was applied to the wound for 15 seconds. The subjects were asked to report the intensity of the stinging/burning sensation during the application. The prototype pramoxine-benzalkonium chloride wipe produced significantly less stinging/burning than both 70% isopropyl alcohol and 3% hydrogen peroxide. Also, the prototype wipe did not produce more stinging and burning in superficial wounds compared to the saline control. |
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Authors:
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A Pagnoni; G Spinelli; R S Berger; J Bowman; S Garreffa; A M Snoddy |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of cosmetic science Volume: 55 ISSN: 1525-7886 ISO Abbreviation: J Cosmet Sci Publication Date: 2004 Mar-Apr |
Date Detail:
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Created Date: 2004-05-07 Completed Date: 2004-07-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9814276 Medline TA: J Cosmet Sci Country: United States |
Other Details:
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Languages: eng Pagination: 157-62 Citation Subset: IM |
Affiliation:
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Hill Top Research, Inc., 388 Ryders Lane, Milltown, NJ 08850, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Adult Anesthetics / administration & dosage*, adverse effects Anti-Infective Agents, Local / administration & dosage*, adverse effects Double-Blind Method Female First Aid* Humans Male Middle Aged Wounds and Injuries / therapy* |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Anti-Infective Agents, Local |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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