Document Detail


Lack of beta-adrenergic activity of isoflurane in the dog: a comparison of circulatory effects of halothane and isoflurane after propranolol administration.
MedLine Citation:
PMID:  14656     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The studies were undertaken to determine whether isoflurance inhalation is associated with a degree of beta-adrenergic action that is potentially important in clinical situations, and to compare the circulatory tolerance to isoflurane and halothane in dogs following beta blockade. We measured arterial and pulmonary artery pressure, left and right ventricular filling pressure, heart rate and cardiac output, and derived stroke volume and systemic and pulmonary vascular resistances in 13 mongrel dogs. The haemodynamic response to 1 MAC and 2 MAC isoflurane was studied in seven dogs and was similar before and after propranolol 0.1mg/kg i.v. In six dogs, propranolol 0.5mg/kg caused no significant changes in the circulatory response to 1 MAC and 2 MAC isoflurane or 1 MAC halothane. However, in three dogs, administration of 2 MAC halothane after propranolol 0.5mg/kg resulted in such profound circulatory depression as to preclude further study. These data suggest that (a) isoflurane possesses no clinically important beta-adrenergic stimulating activity; (b) there is no adverse drug interaction upon the circulation with the combination of isoflurane and propranolol; (c) in the presence of moderated profound beta-adrenergic blockade, 2 MAC isoflurane may be tolerated better than 2 MAC halothane.
Authors:
D M Philbin; E Lowenstein
Related Documents :
8398516 - Towards a standardized anaesthetic state using isoflurane and morphine.
10622646 - Sevoflurane versus isoflurane in patients undergoing coronary artery bypass grafting: a...
2282546 - Use of halothane and isoflurane in the horse.
7361246 - Effects of butorphanol, fentanyl and morphine on the intrabiliary pressure of guinea pigs.
18510786 - Recently published papers: a little less ventilation, a little more oxygen please?
15590996 - Fetal renal and blood pressure responses to steroid infusion after early prenatal treat...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  48     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1976 Dec 
Date Detail:
Created Date:  1977-05-27     Completed Date:  1977-05-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1165-70     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Agonists / pharmacology
Animals
Blood Circulation / drug effects*
Dogs
Drug Tolerance
Halothane / pharmacology*
Isoflurane / pharmacology*
Methyl Ethers / pharmacology*
Propranolol / pharmacology*
Receptors, Adrenergic / drug effects*
Receptors, Adrenergic, beta / drug effects*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Methyl Ethers; 0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 151-67-7/Halothane; 26675-46-7/Isoflurane; 525-66-6/Propranolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Activity profile of carpipramine. Results of an open trial and a double-blind trial versus doxepin
Next Document:  An evaluation of the AVL 937C blood-gas and pH microanalyser.