Document Detail


Lack of association polymorphisms of the IL1RN, IL1A, and IL1B genes with knee osteoarthritis in Turkish patients.
MedLine Citation:
PMID:  17716546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To examine whether polymorphisms of the interleukin 1 receptor antagonist (IL1RN), interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B) genes are markers of genetic susceptibility to knee osteoarthritis in Turkish patients. METHODS: One hundred and seven patients with knee osteoarthritis and 67 controls were studied. Three polymorphisms of IL1A, IL1B, and IL1RN genes were typed from genomic DNA. Allelic frequencies were compared between patients and control subjects. RESULTS: No significant differences were observed in genotype and allele frequencies of the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms between patients and controls. Furthermore, we did not detect any association genotypes of the polymorphisms with the clinical, radiological, and laboratory profiles of patients. CONCLUSIONS: The present study suggest that the IL1RN VNTR, IL1A+4845, IL1B+3953 genes polymorphisms are not genetic markers of susceptibility to knee osteoarthritis in Turkish patients, and are unrelated to the clinical, radiological, and laboratory characteristics of knee osteoarthritis.
Authors:
Malek Sezgin; M Emin Erdal; Zuhal Mert Altintas; Handan Camdeviren Ankarali; I Omer Barlas; Ebru Turkmen; Gunsah Sahin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and investigative medicine. Médecine clinique et experimentale     Volume:  30     ISSN:  1488-2353     ISO Abbreviation:  Clin Invest Med     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-24     Completed Date:  2007-10-11     Revised Date:  2007-12-06    
Medline Journal Info:
Nlm Unique ID:  7804071     Medline TA:  Clin Invest Med     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  E86-92     Citation Subset:  IM    
Affiliation:
Department of Physical Medicine and Rehabilitation, Medical Faculty of Mersin University, Mersin, Turkey. msezgin@mersin.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Aged
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Interleukin 1 Receptor Antagonist Protein / genetics*
Interleukin-1alpha / genetics*
Interleukin-1beta / genetics*
Male
Middle Aged
Osteoarthritis, Knee / genetics,  pathology*
Polymorphism, Genetic*
Turkey
Chemical
Reg. No./Substance:
0/Interleukin 1 Receptor Antagonist Protein; 0/Interleukin-1alpha; 0/Interleukin-1beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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