Document Detail


Lack of association and linkage between HLA and familial polyposis coli.
MedLine Citation:
PMID:  3040576     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated possible association of and linkage between HLA and familial polyposis coli (FPC). In 182 individuals from 66 pedigrees of FPC and 108 individuals from a normal population, HLA-A, -B, and -C antigens were determined. When the frequencies of HLA antigens in 66 unrelated patients and in normal controls were compared, no association of FPC with HLA was observed. For the linkage analysis, HLA haplotypes of 17 affected sib pairs were investigated by the affected sib pair method. The number of pairs which shared two, one, and no haplotypes identical by descent was not significantly different from the number expected with random occurrence (P greater than 0.95). Finally, seven families were analyzed using Morton's sequential test. A maximum lod score of -0.056 at a recombination fraction of 0.4, and a lod of -3.089 at a recombination fraction of 0.05 were obtained. Therefore, there is neither an association of nor linkage between FPC and HLA.
Authors:
M Sasaki; K Sugio; J Soejima; T Ikeuchi; A Tonomura; T Iwama; J Utsunomiya; T Sasazuki
Related Documents :
6520406 - Interactive effect of genes associated with immunoglobulin allotypes and hla specificit...
20403146 - Hla-b*9553: a novel hla allele shown in three generations of a family.
10397736 - Unravelling an hla-dr association in childhood acute lymphoblastic leukemia.
15793356 - Genetic characteristics of the korean isolate ki-1 of toxoplasma gondii.
16341836 - Quantitative trait loci controlling sulfur containing amino acids, methionine and cyste...
12972256 - A comparison of directed evolution approaches using the beta-glucuronidase model system.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  77     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-09     Completed Date:  1987-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyposis Coli / genetics*
Female
Gene Frequency
Genetic Markers
Genotype
HLA Antigens / genetics*
Humans
Linkage (Genetics)*
Male
Pedigree
Chemical
Reg. No./Substance:
0/Genetic Markers; 0/HLA Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Solid glomus tumor of the pterygoid fossa: a lesion mimicking an epithelial neoplasm of low-grade ma...
Next Document:  A small deletion in the Duchenne/Becker muscular dystrophy locus--a functionally important region?