Document Detail

Lack of association and linkage between HLA and familial polyposis coli.
MedLine Citation:
PMID:  3040576     Owner:  NLM     Status:  MEDLINE    
We investigated possible association of and linkage between HLA and familial polyposis coli (FPC). In 182 individuals from 66 pedigrees of FPC and 108 individuals from a normal population, HLA-A, -B, and -C antigens were determined. When the frequencies of HLA antigens in 66 unrelated patients and in normal controls were compared, no association of FPC with HLA was observed. For the linkage analysis, HLA haplotypes of 17 affected sib pairs were investigated by the affected sib pair method. The number of pairs which shared two, one, and no haplotypes identical by descent was not significantly different from the number expected with random occurrence (P greater than 0.95). Finally, seven families were analyzed using Morton's sequential test. A maximum lod score of -0.056 at a recombination fraction of 0.4, and a lod of -3.089 at a recombination fraction of 0.05 were obtained. Therefore, there is neither an association of nor linkage between FPC and HLA.
M Sasaki; K Sugio; J Soejima; T Ikeuchi; A Tonomura; T Iwama; J Utsunomiya; T Sasazuki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  77     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1987 Sep 
Date Detail:
Created Date:  1987-10-09     Completed Date:  1987-10-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  36-9     Citation Subset:  IM    
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MeSH Terms
Adenomatous Polyposis Coli / genetics*
Gene Frequency
Genetic Markers
HLA Antigens / genetics*
Linkage (Genetics)*
Reg. No./Substance:
0/Genetic Markers; 0/HLA Antigens

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