Document Detail

Lack of association of human chemokine receptor gene polymorphisms CCR2-64I and CCR5-Delta32 with autoimmune Addison's disease.
MedLine Citation:
PMID:  15086346     Owner:  NLM     Status:  MEDLINE    
The attraction of leukocytes to tissues is essential for inflammation and the initiation of the autoimmune reaction. The process is controlled by chemokines, which are chemotactic cytokines. We investigated whether human chemokine receptor gene polymorphisms, namely CCR5-Delta32 and CCR2-64I, are associated with susceptibility to autoimmune Addison's disease. Genotyping was performed in 56 patients and 127 healthy controls by a new method using pyrosequencing for CCR2-64I and by polymerase chain reaction and detecting gel for CCR5-Delta32. None of the CCR2 or CCR5 alleles was found to be associated, either positively or negatively, with disease risk. Our results indicate that the CCR2-64I and CCR5-Delta32 gene polymorphisms do not play a major role in conferring genetic risk for, and/or protection against, autoimmune Addison's disease.
G Gambelunghe; M Ghaderi; B Gharizadeh; A Brozzetti; C Tortoioli; P Del Sindaco; C B Sanjeevi; P Hjelmström; A Sirsjö; P Nyren; F Santeusanio; A Falorni
Related Documents :
12849056 - Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics.
15579606 - Update on myasthenia gravis.
15919426 - Long-term immunosuppression for prevention of nonviral disease recurrence.
3692536 - Cyclosporin a inhibits autoimmune experimental tubulointerstitial nephritis.
16240426 - Relationship between the sonographic appearance of the thyroid and the clinical course ...
16878056 - Darier disease: case report with oral manifestations.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics     Volume:  31     ISSN:  0960-7420     ISO Abbreviation:  Eur. J. Immunogenet.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2005-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106962     Medline TA:  Eur J Immunogenet     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Department of Internal Medicine, University of Perugia, Perugia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Addison Disease / genetics*
Gene Frequency
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Receptors, CCR2
Receptors, CCR5 / chemistry*
Receptors, Chemokine / genetics*
Reg. No./Substance:
0/CCR2 protein, human; 0/Receptors, CCR2; 0/Receptors, CCR5; 0/Receptors, Chemokine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  MICA polymorphism in a sample of the São Paulo population, Brazil.
Next Document:  T-cell receptor BV gene segment polymorphisms in healthy elderly individuals from the south of Brazi...