Document Detail


Lack of association of human chemokine receptor gene polymorphisms CCR2-64I and CCR5-Delta32 with autoimmune Addison's disease.
MedLine Citation:
PMID:  15086346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The attraction of leukocytes to tissues is essential for inflammation and the initiation of the autoimmune reaction. The process is controlled by chemokines, which are chemotactic cytokines. We investigated whether human chemokine receptor gene polymorphisms, namely CCR5-Delta32 and CCR2-64I, are associated with susceptibility to autoimmune Addison's disease. Genotyping was performed in 56 patients and 127 healthy controls by a new method using pyrosequencing for CCR2-64I and by polymerase chain reaction and detecting gel for CCR5-Delta32. None of the CCR2 or CCR5 alleles was found to be associated, either positively or negatively, with disease risk. Our results indicate that the CCR2-64I and CCR5-Delta32 gene polymorphisms do not play a major role in conferring genetic risk for, and/or protection against, autoimmune Addison's disease.
Authors:
G Gambelunghe; M Ghaderi; B Gharizadeh; A Brozzetti; C Tortoioli; P Del Sindaco; C B Sanjeevi; P Hjelmström; A Sirsjö; P Nyren; F Santeusanio; A Falorni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics     Volume:  31     ISSN:  0960-7420     ISO Abbreviation:  Eur. J. Immunogenet.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2005-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9106962     Medline TA:  Eur J Immunogenet     Country:  England    
Other Details:
Languages:  eng     Pagination:  73-6     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Perugia, Perugia, Italy. giovanni.gambelunghe@libero.it
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MeSH Terms
Descriptor/Qualifier:
Addison Disease / genetics*
Adult
Aged
Alleles
Child
Female
Gene Frequency
Haplotypes
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Genetic*
Receptors, CCR2
Receptors, CCR5 / chemistry*
Receptors, Chemokine / genetics*
Chemical
Reg. No./Substance:
0/CCR2 protein, human; 0/Receptors, CCR2; 0/Receptors, CCR5; 0/Receptors, Chemokine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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