Document Detail

Lack of association of chromosome 9p21.3 genotype with cardiovascular structure and function in persons with stable coronary artery disease: The Heart and Soul Study.
MedLine Citation:
PMID:  19171343     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Recent large-scale genome-wide association studies have identified a novel susceptibility locus on chromosome 9p21.3 that contributes a significant attributable risk for myocardial infarction. The phenotypic significance of this locus in patients with established coronary artery disease is unknown. We sought to compare cardiovascular structure and function in carriers and non-carriers of the risk haplotype in a cross-sectional study.
METHODS: We genotyped the rs1333049 single-nucleotide polymorphism in 593 Caucasian individuals with stable coronary artery disease recruited in the Heart and Soul Study. All study subjects underwent resting and stress echocardiography. Linear and logistic regression models were used to examine the association between the rs1333049 polymorphism and echocardiographic parameters of cardiovascular structure and function.
RESULTS: There was no association between rs1333049 genotype and echocardiographic phenotype (left ventricular hypertrophy, systolic dysfunction, diastolic dysfunction, inducible ischemia, exercise capacity, mitral annular calcification, and aortic plaque).
CONCLUSIONS: In a cross-sectional study of individuals with stable coronary artery disease, there was no association of chromosome 9p21.3 genotype with cardiovascular structure and function.
Ramin Farzaneh-Far; Beeya Na; Nelson B Schiller; Mary A Whooley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-12-30
Journal Detail:
Title:  Atherosclerosis     Volume:  205     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-28     Completed Date:  2009-12-03     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  IM    
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MeSH Terms
Cardiovascular System*
Chromosomes, Human, Pair 9*
Cohort Studies
Coronary Artery Disease / genetics*
Cross-Sectional Studies
Echocardiography / methods
Middle Aged
Polymorphism, Single Nucleotide
Regression Analysis
Risk Factors
Grant Support
R01 HL079235/HL/NHLBI NIH HHS; R01 HL079235/HL/NHLBI NIH HHS; R01 HL079235-01A1/HL/NHLBI NIH HHS; R01 HL079235-02/HL/NHLBI NIH HHS; R01 HL079235-03/HL/NHLBI NIH HHS; R01 HL079235-04/HL/NHLBI NIH HHS
Comment In:
Atherosclerosis. 2009 Aug;205(2):367; author reply 368   [PMID:  19409564 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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